Evidence map›Paper›PMID 19308300›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2009

Peripheral arterial disease and osteoporosis in older adults: the Rancho Bernardo Study.

D von Mühlen, M Allison, S K Jassal, E Barrett-Connor

Open access · hybridAbstract read
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. The association between peripheral arterial disease and risk for hip fractures in elderly men is not explained by low hip bone mineral density. Results from the MrOS Sweden study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Observational
  5. Article
  6. Article
  7. Article
  8. Vitamin D and cardiovascular disorders.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Review
  9. Review
  10. The associations of subclinical atherosclerotic cardiovascular disease with hip fracture risk and bone mineral density in elderly adults.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Article
  11. Article
  12. Risk and outcomes of fracture in peripheral arterial disease patients: two nationwide cohort studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Article
  13. Article
  14. Decreased bone cortical density at the forearm in subjects with subclinical peripheral arterial disease.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Article
  15. Ankle-brachial index and bone turnover in patients on dialysis.Journal of the American Society of Nephrology : JASN · 2015
    Article
  16. High hip fracture risk in men with severe aortic calcification: MrOS study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014
    Article
  17. Association of volumetric bone mineral density with abdominal aortic calcification in African ancestry men.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Article
  18. Challenges associated with peripheral arterial disease in women.Vascular health and risk management · 2014
    Review
  19. Article
  20. Evidence for a genetic link between bone and vascular measures in African ancestry families.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

D von MühlenDivision of Epidemiology, Department of Family and Preventive Medicine, University of California, La Jolla, San Diego, CA, USA. dvonmuhlen@ucsd.edu
M Allison
S K Jassal
E Barrett-Connor
University of California System · USUniversity of California, San Diego · USVA San Diego Healthcare System · US

Funding

STUDY OF RISK FACTORS FOR OSTEOPOROSIS IN THE ELDERLYR37AG007181 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BARRETT-CONNOR, ELIZABETH L · 1987 to 2010
$5.4M
GENDER DIFFERENCES IN OSTEOPOROSISR01AG007181 · NIA · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI BARRETT-CONNOR, ELIZABETH L · 1999 to 2002
$1.6M
EPIDEMIOLOGY OF NIDDM AND IGT IN AN ADULT COMMUNITYR01DK031801 · NIDDK · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI BARRETT-CONNOR, ELIZABETH L · 1986 to 2000
$606k
NIA NIH HHS AG07181NIA NIH HHS R01 AG007181NIA NIH HHS R37 AG007181NIDDK NIH HHS R01 DK031801
6 · The paper itself

Abstract

summaryWe examined the association between peripheral arterial disease (PAD) and bone health in 1,332 adults. We found a weak association between PAD and osteoporosis and bone loss only in women, but the association was not independent of age. PAD was not associated with fractures in this community-based population.

introductionIncreased rates of osteoporosis have been reported in patients with cardiovascular disease, suggesting a link between osteoporosis and atherosclerosis.

methodsWe examined the association between PAD and bone health in 1,332 adults who attended a research visit in 1992-1996, when the ankle-brachial index (ABI), bone mineral density (BMD), and spine X-rays were obtained. A total of 837 participants attended a follow-up visit in 1997-2000.

resultsPAD defined by an ABI < or = 0.90 was present in 15.4% of the women and 13.3% of the men. Prevalence of osteoporosis was significantly higher in women with PAD compared to women without PAD (p < 0.05). During an average 4-year follow-up, women with PAD had a significantly higher rate of bone loss than women without PAD (p = 0.05). The associations were no longer significant after age adjustment. In men, PAD was not associated with osteoporosis, but men with PAD had lower BMD at the femoral neck than men without PAD (p = 0.03). PAD was not associated with osteoporotic fractures in either sex.

conclusionWe found a weak and age-dependent association between PAD and osteoporosis in women but not men. PAD was not associated with fractures in this community-based population.

Indexed as

AdultAgedAged, 80 and overBone DensityCaliforniaEpidemiologic MethodsFemaleFemur NeckHip JointHumansMaleMiddle AgedOsteoporosisOsteoporotic FracturesPeripheral Arterial DiseaseSex Factors

Identifiers

PMID19308300
PMCPMC2777212
OpenAlexW2095893192

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.