ArticleNeoplasia (New York, N.Y.)2009
PDCD5 interacts with Tip60 and functions as a cooperator in acetyltransferase activity and DNA damage-induced apoptosis.
Article in Neoplasia (New York, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 74 citations in OpenAlex.
- KAT5: the epigenetic regulator of central nervous system diseases.Frontiers in molecular neuroscience · 2026Review
- Review
- Insights into Regulators of p53 Acetylation.Cells · 2022Review
- The role of protein acetylation in carcinogenesis and targeted drug discovery.Frontiers in endocrinology · 2022Review
- Article
- Club cell-specific role of programmed cell death 5 in pulmonary fibrosis.Nature communications · 2021Article
- PDCD5 regulates iNKT cell terminal maturation and iNKT1 fate decision.Cellular & molecular immunology · 2019Article
- Effects of Tumor Necrosis Factor Alpha on the Expression of Programmed Cell Death Factor 5 in Arthritis.Orthopaedic surgery · 2019Article
- Effect of Tiotropium Bromide on Airway Inflammation and Programmed Cell Death 5 in a Mouse Model of Ovalbumin-Induced Allergic Asthma.Canadian respiratory journal · 2019Article
- Histone acetyl transferase TIP60 inhibits the replication of influenza a virus by activation the TBK1-IRF3 pathway.Virology journal · 2018Article
- PDCD5 regulates cell proliferation, cell cycle progression and apoptosis.Oncology letters · 2018Article
- Programmed cell death 5 transgenic mice attenuates adjuvant induced arthritis by 2 modifying the T lymphocytes balance.Biological research · 2017Article
- Deletion of Pdcd5 in mice led to the deficiency of placenta development and embryonic lethality.Cell death & disease · 2017Article
- Overexpression of programmed cell death 5 in a mouse model of ovalbumin-induced allergic asthma.BMC pulmonary medicine · 2016Article
- AtPDCD5 Plays a Role in Programmed Cell Death after UV-B Exposure in Arabidopsis.Plant physiology · 2016Article
- The reduced PDCD5 protein is correlated with the degree of tumor differentiation in endometrioid endometrial carcinoma.SpringerPlus · 2016Article
- Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response.Nature communications · 2015Article
- Recombinant human PDCD5 (rhPDCD5) protein is protective in a mouse model of multiple sclerosis.Journal of neuroinflammation · 2015Article
- The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death.Scientific reports · 2015Article
- Staphylococcus aureus induces hypoxia and cellular damage in porcine dermal explants.Infection and immunity · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tip60 is a histone acetyltransferase (HAT) involved in the acetyltransferase activity and the cellular response to DNA damage. Here, we show that programmed cell death 5 (PDCD5), a human apoptosis-related protein, binds to Tip60 and enhances the stability of Tip60 protein in unstressed conditions. The binding amount of PDCD5 and Tip60 is significantly increased after UV irradiation. Further, PDCD5 enhances HAT activity of Tip60 and Tip60-dependent histone acetylation in both basal and UV-induced levels. We also find that PDCD5 increases Tip60-dependent K120 acetylation of p53 and participates in the p53-dependent expression of apoptosis-related genes, such as Bax. Moreover, we demonstrate the biological significance of the PDCD5-Tip60 interaction; that is, they function in cooperation to accelerate DNA damage-induced apoptosis and knockdown of PDCD5 or Tip60 impairs their apoptosis-accelerating activity, mutually. Consistent with this, PDCD5 levels increase significantly on DNA damage in U2OS cells, as does Tip60. Together, our findings indicate that PDCD5 may play a dual role in the Tip60 pathway. Specifically, under normal growth conditions, PDCD5 contributes to maintaining a basal pool of Tip60 and its HAT activity. After DNA damage, PDCD5 functions as a Tip60 coactivator to promote apoptosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.