ArticleExperimental & molecular medicine2009
Polymorphisms of COTL1 gene identified by proteomic approach and their association with autoimmune disorders.
Article in Experimental & molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Phosphoproteomic profiling of early rheumatoid arthritis synovium reveals active signalling pathways and differentiates inflammatory pathotypes.Arthritis research & therapy · 2024Article
- Coactosin-like protein 1 regulates integrity and repair of model intestinal epithelial barriers via actin binding dependent and independent mechanisms.Frontiers in cell and developmental biology · 2024Article
- A 9 mRNAs-based diagnostic signature for rheumatoid arthritis by integrating bioinformatic analysis and machine-learning.Journal of orthopaedic surgery and research · 2021Article
- Identification of PBMC-expressed miRNAs for rheumatoid arthritis.Epigenetics · 2020Article
- Coactosin-Like Protein (COTL1) Promotes Glioblastoma (GBM) Growth in vitro and in vivo.Cancer management and research · 2020Article
- Bone Morphogenetic Protein 6 Polymorphisms are Associated With Systemic Lupus Erythematosus Susceptibility in the Korean Population.Archives of rheumatology · 2018Article
- Further studies about Coactosin-like protein-1 affecting the migration of mouse neocortical neurons.Journal of molecular histology · 2018Article
- Proteomics in Rheumatoid Arthritis Research.Immune network · 2015Review
- The Association of the GABRP Polymorphisms with Systemic Lupus Erythematosus.Journal of immunology research · 2015Article
- Identification of potential serum biomarkers for rheumatoid arthritis by high-resolution quantitative proteomic analysis.Inflammation · 2014Article
- Proteomics identifies differentially expressed proteins in neonatal murine thymus compared with adults.Proteome science · 2012Article
- A comparative proteomic study of sera in paediatric systemic lupus erythematosus patients and in healthy controls using MALDI-TOF-TOF and LC MS-A pilot study.Pediatric rheumatology online journal · 2012Article
- The haplotypes of TNFRSF17 polymorphisms are associated with colon cancer in a Korean population.International journal of colorectal disease · 2012Article
- Impaired glycolytic response in peripheral blood mononuclear cells of first-onset antipsychotic-naive schizophrenia patients.Molecular psychiatry · 2011Article
- Proteomics in rheumatology: the dawn of a new era.F1000 medicine reports · 2010Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To select candidate genes, we attempted to comparative analysis of protein levels between rheumatoid arthritis (RA) patients and healthy controls by two-dimensional electrophoresis (2-DE) and matrix-assisted laser desorption ionization mass spectrometry (MALDI-TOF-MS). We identified 17 proteins that showed up- or down-regulated spots in RA patients. We found that coactosin-like1 (COTL1) were highly expressed in RA patients compared with healthy controls. We performed a case-control study to determine whether the COTL1 gene polymorphisms were associated with RA and systemic lupus erythematosus (SLE). The genotype frequency of c.-1124G>T and the allelic frequency of c.484G>A in RA patients, and the genotype frequency of c.484G>A in SLE patients were significantly different from healthy controls (P=0.009, 0.027, and 0.025, respectively). We also investigated the correlation with the levels of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibody in RA patients, and anti-nuclear antibodies (ANA) in SLE patients. The c.484G>A polymorphism in RA patients has significant association with the levels of anti-CCP antibody (P=0.03). Our findings demonstrated that c.-1124G>T and c. 484G>A polymorphisms of the COTL1 gene might be associated with the genetic susceptibility of autoimmune disorders.
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