ArticleExperimental & molecular medicine2009
Chromosomal instability is more frequent in metastasized than in non-metastasized pulmonary carcinoids but is not a reliable predictor of metastatic potential.
Article in Experimental & molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Small cell lung cancer and neuroendocrine tumours.Breathe (Sheffield, England) · 2024Review
- Mechanical stress during confined migration causes aberrant mitoses and c-MYC amplification.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Review
- Morphologic and molecular classification of lung neuroendocrine neoplasms.Virchows Archiv : an international journal of pathology · 2021Review
- Review
- PI3K/AKT/mTOR pathway in pulmonary carcinoid tumours.Oncology letters · 2017Article
- [Diagnosis, prognosis, and prediction of non-small cell lung cancer. Importance of morphology, immunohistochemistry and molecular pathology].Der Pathologe · 2015Review
- [Pulmonary neuroendocrine tumors in the new WHO 2015 classification: Start of breaking new grounds?].Der Pathologe · 2015Review
- Genetics of pancreatic neuroendocrine tumors: implications for the clinic.Expert review of gastroenterology & hepatology · 2015Review
- [Molecular pathology of lung cancer. State of the art 2014].Der Pathologe · 2014Review
- [Neuroendocrine tumors of the lungs. From small cell lung carcinoma to diffuse idiopathic pulmonary neuroendocrine cell hyperplasia].Der Pathologe · 2014Review
- The cancer biology of whole-chromosome instability.Oncogene · 2013Review
- [Novel morphological and molecular aspects of lung cancer].Der Pathologe · 2013Review
- Interobserver agreement of proliferation index (Ki-67) outperforms mitotic count in pulmonary carcinoids.Virchows Archiv : an international journal of pathology · 2013Article
- Phenotyping of pulmonary carcinoids and a Ki-67-based grading approach.Virchows Archiv : an international journal of pathology · 2012Article
- Deletions of 11q22.3-q25 are associated with atypical lung carcinoids and poor clinical outcome.The American journal of pathology · 2011Article
- Chromosomes and cancer cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Review
- [S100 protein positive sustentacular cells in pulmonary carcinoids and thoracic paragangliomas: differential diagnostic and prognostic evaluation].Der Pathologe · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary carcinoids are infrequent neoplasms of the lung that normally display a less aggressive biological behavior compared to small cell and non-small cell lung cancers. Approximately 15-25% of carcinoids, in particular atypical carcinoids, show lymph node metastasis and have a worse prognosis than their non-metastasized counterparts. To date, there is no morphological or molecular marker that may help to differentiate between carcinoids that metastasize and carcinoids of identical differentiation that show only local tumor growth. In this study, we analyzed 7 metastasized and 10 non-metastasized pulmonary carcinoids for chromosomal and microsatellite instability in order to determine whether microsatellite instability or chromosomal imbalances are associated with metastasis. Due to the rare occurrence of metastasized carcinoids we compared our results of chromosomal instability with the hitherto published comparative genomic hybridization (CGH) profiles of pulmonary carcinoids, for which information about the absence or presence of metastasis was available. While microsatellite instability was not detected we found chromosomal instability as a common event in pulmonary carcinoids with an increase of frequency and extent of chromosomal alterations in atypical and metastasized carcinoids. These findings are in accordance with the collected and herein compiled data of previous studies and indicate increasing numbers of chromosomal imbalances to play a role in the sequential process of tumor development and metastasis.
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