ArticleThe Journal of clinical investigation2009
Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice.
Article in The Journal of clinical investigation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
- Phenotypic and genomic study of digital dermatitis in UK Holstein heifers.BMC genomics · 2026Article
- Spectrin coordinates cell shape and signaling essential for epidermal differentiation.The Journal of cell biology · 2026Article
- Targeted siRNA Therapy for Psoriasis: Translating Preclinical Potential into Clinical Treatments.ImmunoTargets and therapy · 2024Review
- Transcriptional profiling of rare acantholytic disorders suggests common mechanisms of pathogenesis.JCI insight · 2023Article
- Mechanical regulation of chromatin and transcription.Nature reviews. Genetics · 2022Review
- Anillin governs mitotic rounding during early epidermal development.BMC biology · 2022Article
- Epidermis-Intrinsic Transcription Factor Ovol1 Coordinately Regulates Barrier Maintenance and Neutrophil Accumulation in Psoriasis-Like Inflammation.The Journal of investigative dermatology · 2022Article
- Exploring a Role for Regulatory miRNAs In Wound Healing during Ageing:Involvement of miR-200c in wound repair.Scientific reports · 2017Article
- Desmosomes and Intermediate Filaments: Their Consequences for Tissue Mechanics.Cold Spring Harbor perspectives in biology · 2017Review
- Mechanoregulation of Wound Healing and Skin Homeostasis.BioMed research international · 2016Review
- Endothelial depletion of murine SRF/MRTF provokes intracerebral hemorrhagic stroke.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Serum response factor: positive and negative regulation of an epithelial gene expression network in the destrin mutant cornea.Physiological genomics · 2014Article
- Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1.The Journal of cell biology · 2013Article
- Endothelial SRF/MRTF ablation causes vascular disease phenotypes in murine retinae.The Journal of clinical investigation · 2013Article
- Serum response factor is required for cortical axon growth but is dispensable for neurogenesis and neocortical lamination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis.Nature reviews. Molecular cell biology · 2011Review
- Article
- Serum response factor is required for cell contact maintenance but dispensable for proliferation in visceral yolk sac endothelium.BMC developmental biology · 2011Article
- Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation.Nature cell biology · 2011Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor serum response factor (SRF) plays a crucial role in the development of several organs. However, its role in the skin has not been explored. Here, we show that keratinocytes in normal human and mouse skin expressed high levels of SRF but that SRF expression was strongly downregulated in the hyperproliferative epidermis of wounded and psoriatic skin. Keratinocyte-specific deletion within the mouse SRF locus during embryonic development caused edema and skin blistering, and all animals died in utero. Postnatal loss of mouse SRF in keratinocytes resulted in the development of psoriasis-like skin lesions. These lesions were characterized by inflammation, hyperproliferation, and abnormal differentiation of keratinocytes as well as by disruption of the actin cytoskeleton. Ultrastructural analysis revealed markedly reduced cell-cell and cell-matrix contacts and loss of cell compaction in all epidermal layers. siRNA-mediated knockdown of SRF in primary human keratinocytes revealed that the cytoskeletal abnormalities and adhesion defects were a direct consequence of the loss of SRF. In contrast, the hyperproliferation observed in vivo was an indirect effect that was most likely a consequence of the inflammation. These results reveal that loss of SRF disrupts epidermal homeostasis and strongly suggest its involvement in the pathogenesis of hyperproliferative skin diseases, including psoriasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.