ArticleThe Journal of cell biology2009
NF-kappaB and Snail1a coordinate the cell cycle with gastrulation.
Article in The Journal of cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
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- Gallbladder-derived retinoic acid signalling drives reconstruction of the damaged intrahepatic biliary ducts.Nature cell biology · 2025Article
- Meningeal lymphatic supporting cells govern the formation and maintenance of zebrafish mural lymphatic endothelial cells.Nature communications · 2024Article
- DNA methylation maintenance at the p53 locus initiates biliary-mediated liver regeneration.NPJ Regenerative medicine · 2022Article
- Mcm5 Represses Endodermal Migration through Cxcr4a-itgb1b Cascade Instead of Cell Cycle Control.Biomolecules · 2022Article
- Mild cold stress specifically disturbs clustering movement of DFCs and sequential organ left-right patterning in zebrafish.Frontiers in cell and developmental biology · 2022Article
- A single-cell-resolution fate map of endoderm reveals demarcation of pancreatic progenitors by cell cycle.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Zebrafish Klf4 maintains the ionocyte progenitor population by regulating epidermal stem cell proliferation and lateral inhibition.PLoS genetics · 2019Article
- Geminin Orchestrates Somite Formation by Regulating Fgf8 and Notch Signaling.BioMed research international · 2018Article
- Article
- Cyp2aa9 regulates haematopoietic stem cell development in zebrafish.Scientific reports · 2016Article
- Geminin promotes an epithelial-to-mesenchymal transition in an embryonic stem cell model of gastrulation.Stem cells and development · 2013Article
- Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Geminin is required for epithelial to mesenchymal transition at gastrulation.Stem cells and development · 2012Article
- Retinoic acid signaling sequentially controls visceral and heart laterality in zebrafish.The Journal of biological chemistry · 2011Article
- Differential regulation of p53 function by the N-terminal ΔNp53 and Δ113p53 isoforms in zebrafish embryos.BMC developmental biology · 2010Article
- Ouabain protects against adverse developmental programming of the kidney.Nature communications · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cell cycle needs to strictly coordinate with developmental processes to ensure correct generation of the body plan and different tissues. However, the molecular mechanism underlying the coordination remains largely unknown. In this study, we investigate how the cell cycle coordinates gastrulation cell movements in zebrafish. We present a system to modulate the cell cycle in early zebrafish embryos by manipulating the geminin-Cdt1 balance. Alterations of the cell cycle change the apoptotic level during gastrulation, which correlates with the nuclear level of antiapoptotic nuclear factor kappaB (NF-kappaB). NF-kappaB associates with the Snail1a promoter region on the chromatin and directly activates Snail1a, an important factor controlling cell delamination, which is the initial step of mesendodermal cell movements during gastrulation. In effect, the cell cycle coordinates the delamination of mesendodermal cells through the transcription of Snail1a. Our results suggest a molecular mechanism by which NF-kappaB and Snail1a coordinate the cell cycle through gastrulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.