ArticleThe Journal of biological chemistry2009
Dissection of mechanisms involved in the regulation of Plasmodium falciparum calcium-dependent protein kinase 4.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Dissecting The role ofEmerging microbes & infections · 2022Article
- Article
- CDPKs: The critical decoders of calcium signal at various stages of malaria parasite development.Computational and structural biotechnology journal · 2021Review
- Malaria and tuberculosis as diseases of neglected populations: state of the art in chemotherapy and advances in the search for new drugs.Memorias do Instituto Oswaldo Cruz · 2020Review
- Proteins with calmodulin-like domains: structures and functional roles.Cellular and molecular life sciences : CMLS · 2019Review
- Plasmodium falciparum apicoplast and its transcriptional regulation through calcium signaling.Journal of microbiology (Seoul, Korea) · 2017Review
- Analysis of Noncanonical Calcium-Dependent Protein Kinases in Toxoplasma gondii by Targeted Gene Deletion Using CRISPR/Cas9.Infection and immunity · 2016Article
- Molecular Characterization and Functional Analysis of a Novel Calcium-Dependent Protein Kinase 4 from Eimeria tenella.PloS one · 2016Article
- Enzyme Activity Assays for Protein Kinases: Strategies to Identify Active Substrates.Current drug discovery technologies · 2016Review
- Allosteric activation of apicomplexan calcium-dependent protein kinases.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Designing selective inhibitors for calcium-dependent protein kinases in apicomplexans.Trends in pharmacological sciences · 2015Review
- The Toxoplasma gondii calcium-dependent protein kinase 7 is involved in early steps of parasite division and is crucial for parasite survival.Cellular microbiology · 2014Article
- Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion.The Journal of biological chemistry · 2013Article
- An evolutionary perspective on the kinome of malaria parasites.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Novel insights into the regulation of malarial calcium-dependent protein kinase 1.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- PfSRPK1, a novel splicing-related kinase from Plasmodium falciparum.The Journal of biological chemistry · 2010Article
- Molecular cloning of Plasmodium vivax calcium-dependent protein kinase 4.The Korean journal of parasitology · 2010Article
- Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium.Nature structural & molecular biology · 2010Article
- The coming-out of malaria gametocytes.Journal of biomedicine & biotechnology · 2010Review
- Calcium-dependent signaling and kinases in apicomplexan parasites.Cell host & microbe · 2009Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Recent studies have demonstrated that calcium-dependent protein kinases (CDPKs) are used by calcium to regulate a variety of biological processes in the malaria parasite Plasmodium. CDPK4 has emerged as an important enzyme for parasite development, because its gene disruption in rodent parasite Plasmodium berghei causes major defects in sexual differentiation of the parasite ( Billker, O., Dechamps, S., Tewari, R., Wenig, G., Franke-Fayard, B., and Brinkmann, V. (2004) Cell 117, 503-514 ). Despite these findings, it is not very clear how PfCDPK4 or any other PfCDPK is regulated by calcium at the molecular level. We report the biochemical characterization and elucidation of molecular mechanisms involved in the regulation of PfCDPK4. PfCDPK4 was detected on gametocyte periphery, and its activity in the parasite was regulated by phospholipase C. Even though the Junction Domain (JD) of PfCDPK4 shares moderate sequence homology with that of the plant CDPKs, it plays a pivotal role in PfCDPK4 regulation as previously reported for some plant CDPKs. The regions of the J-domain involved in interaction with both the kinase domain and the calmodulin-like domain were mapped. We propose a model for PfCDPK regulation by calcium, which may also prove useful for design of inhibitors against PfCDPK4 and other members of the PfCDPK family.
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