ArticleJournal of autoimmunity
The etiology of autoimmune thyroid disease: a story of genes and environment.
Article in Journal of autoimmunity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 4 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
143 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Prenatal exposure to air pollution and maternal and fetal thyroid function: a systematic review of the epidemiological evidence.Environmental health : a global access science source · 2024Pooled it
- Salivary Alterations in Autoimmune Thyroid Diseases: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Cytotoxic T-lymphocyte associated antigen 4 polymorphism and Hashimoto's thyroiditis susceptibility: a meta-analysis.Endocrine · 2014Pooled it
- Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals.Human molecular genetics · 2010Pooled it
- Iodine and Its Impact on the Immune System of Humans and Domesticated Mammals: A Narrative Review.Nutrients · 2026Review
- Thyroid nodule and autoimmune thyroid disease frequency in adults with inborn errors of immunity: a case-control study.BMC immunology · 2026Article
- Reduced Circulating MOTS-c Levels in Hashimoto's Thyroiditis Reflect Integrated Autoimmune and Metabolic Dysregulation: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Thyroid hormone resistance beta and autoimmune thyroid disease - a family case study highlighting diagnostic and therapeutic challenges.Cardiovascular diabetology. Endocrinology reports · 2026Article
- Associations between women's childhood maltreatment and thyroid function before and during pregnancy.Scientific reports · 2026Article
- The role of gut microbiota in autoimmune thyroid diseases: nutritional determinants and diet-based modulation.Frontiers in endocrinology · 2026Review
- Advances in genetic and molecular insights into thyroid disorders: Implications for diagnosis, prognosis, and personalized treatment.Saudi medical journal · 2025Review
- Autoimmune thyroid disease in inborn errors of immunity: a retrospective perspective.Orphanet journal of rare diseases · 2025Article
- Exploring the determinants of thyroid disorders in high-altitude western Himalaya: a geospatial and epidemiological study.Journal of health, population, and nutrition · 2025Article
- Potential of bone marrow mesenchymal stem cells in iodine-induced autoimmune thyroiditis therapy.European thyroid journal · 2025Article
- Genetic aspects of pediatric nephrotic syndrome and anti-nephrin antibodies.Clinical and experimental nephrology · 2025Review
- Clonal hematopoiesis of indeterminate potential and risk of autoimmune thyroid disease.BMC medicine · 2025Article
- Exploring the Correlation Between Varied Serum Iodine Nutritional Levels and Anti-Thyroglobulin Antibodies.Biological trace element research · 2025Article
- HPV vaccine-related thyroid adverse events: temporal patterns and reporting trends.Frontiers in pharmacology · 2025Article
- Clinical presentation and outcome of Graves disease in pediatric patients with and without type 1 diabetes: a retrospective cohort study.Frontiers in endocrinology · 2025Article
- Review
83 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Autoimmune thyroid diseases (AITDs), including Graves' disease (GD) and Hashimoto's thyroiditis (HT) are prevalent autoimmune diseases, affecting up to 5% of the general population. Autoimmune thyroid diseases arise due to complex interactions between environmental and genetic factors. Significant progress has been made in our understanding of the genetic and environmental triggers contributing to AITD. However, the interactions between genes and environment are yet to be defined. Among the major AITD susceptibility genes that have been identified and characterized is the HLA-DR gene locus, as well as non-MHC genes including the CTLA-4, CD40, PTPN22, thyroglobulin, and TSH receptor genes. The major environmental triggers of AITD include iodine, medications, infection, smoking, and possibly stress. Recent data on the genetic predisposition to AITD lead to novel putative mechanisms by which the genetic-environmental interactions may lead to the development of thyroid autoimmunity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.