ArticleThe Journal of clinical investigation2009
NO more muscle fatigue.
Article in The Journal of clinical investigation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Candidate gene polymorphisms and power athlete status: a meta-analytical approach.Journal of physiology and biochemistry · 2025Pooled it
- Renshen Yangrong decoction for secondary malaise and fatigue: network pharmacology and Mendelian randomization study.Frontiers in nutrition · 2024Article
- Key concepts in muscle regeneration: muscle "cellular ecology" integrates a gestalt of cellular cross-talk, motility, and activity to remodel structure and restore function.European journal of applied physiology · 2022Review
- Postcontractile blood oxygenation level-dependent (BOLD) response in Duchenne muscular dystrophy.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Exercise therapy in muscle diseases: open issues and future perspectives.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2019Article
- Associations Between Neurotransmitter Genes and Fatigue and Energy Levels in Women After Breast Cancer Surgery.Journal of pain and symptom management · 2017Article
- Galectin-1 Protein Therapy Prevents Pathology and Improves Muscle Function in the mdx Mouse Model of Duchenne Muscular Dystrophy.Molecular therapy : the journal of the American Society of Gene Therapy · 2015Article
- Muscle exercise in limb girdle muscular dystrophies: pitfall and advantages.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2015Review
- Muscle fatigue, nNOS and muscle fiber atrophy in limb girdle muscular dystrophy.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2014Review
- Fluoxetine prevents dystrophic changes in a zebrafish model of Duchenne muscular dystrophy.Human molecular genetics · 2014Article
- Blockade of ActRIIB signaling triggers muscle fatigability and metabolic myopathy.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling.Human molecular genetics · 2014Article
- Genes for elite power and sprint performance: ACTN3 leads the way.Sports medicine (Auckland, N.Z.) · 2013Review
- Fatigue in muscular dystrophies.Neuromuscular disorders : NMD · 2012Review
- Distinct genetic regions modify specific muscle groups in muscular dystrophy.Physiological genomics · 2011Article
- Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and disease.Free radical biology & medicine · 2010Review
- The -786 T/C polymorphism of the NOS3 gene is associated with elite performance in power sports.European journal of applied physiology · 2009Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
NOS is a key enzyme in the production of NO, a molecule that directly regulates vasorelaxation and blood supply. Diverse forms of muscle disease have been clinically associated with unusual fatigue after exercise. The localization of neuronal NOS (nNOS) at the plasma membrane of muscle has recently been shown to prevent muscle fatigue after exercise. In this issue of the JCI, Lai et al. show that dystrophin--the structural protein missing in individuals with Duchenne muscular dystrophy--anchors nNOS to the sarcolemma through a direct interaction with dystrophin spectrin-like repeats 16 and 17 (see the related article, doi:10.1172/JCI36612). Furthermore, in another recently reported study of mouse models of muscular dystrophy, phosphodiesterase 5A inhibitors were used to treat the downstream ischemia that is associated with nNOS mislocalization. Collectively, these findings significantly advance our understanding of exercise-induced muscle fatigue and its role in muscle disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.