ReviewBirth defects research. Part C, Embryo today : reviews2009
Genomic landscape of developing male germ cells.
Review in Birth defects research. Part C, Embryo today : reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Differentiation of Human Wharton Jelly Mesenchymal Stem Cells into Germ-Like Cells; emphasis on evaluation of Germ-long non-coding RNAs.Molecular biology reports · 2022Article
- TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation.Autophagy · 2021Article
- Aristolochic acid I induces impairment in spermatogonial stem cell in rodents.Toxicology research · 2021Article
- MAGE cancer-testis antigens protect the mammalian germline under environmental stress.Science advances · 2019Article
- Cstf2t Regulates expression of histones and histone-like proteins in male germ cells.Andrology · 2018Article
- Cellular and molecular characterization of gametogenic progression in ex vivo cultured prepuberal mouse testes.Reproductive biology and endocrinology : RB&E · 2017Article
- Natural Antisense Transcripts at the Interface between Host Genome and Mobile Genetic Elements.Frontiers in microbiology · 2017Article
- GermlncRNA: a unique catalogue of long non-coding RNAs and associated regulations in male germ cell development.Database : the journal of biological databases and curation · 2015Article
- Male-specific region of the bovine Y chromosome is gene rich with a high transcriptomic activity in testis development.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Integrative proteomic and transcriptomic analyses reveal multiple post-transcriptional regulatory mechanisms of mouse spermatogenesis.Molecular & cellular proteomics : MCP · 2013Article
- Genome-wide analysis reveals distinct patterns of epigenetic features in long non-coding RNA loci.Nucleic acids research · 2012Article
- Transcriptional regulatory circuitries in the human pathogen Candida albicans involving sense--antisense interactions.Genetics · 2012Article
- Identification of novel long noncoding RNA transcripts in male germ cells.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Article
- Revealing the transcriptome landscape of mouse spermatogonial cells by tiling microarray.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Small RNAs in early mammalian development: from gametes to gastrulation.Development (Cambridge, England) · 2011Review
- Article
- Testicular postgenomics: targeting the regulation of spermatogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Splicing factor and exon profiling across human tissues.Nucleic acids research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Spermatogenesis is a highly orchestrated developmental process by which spermatogonia develop into mature spermatozoa. This process involves many testis- or male germ cell-specific gene products whose expressions are strictly regulated. In the past decade the advent of high-throughput gene expression analytical techniques has made functional genomic studies of this process, particularly in model animals such as mice and rats, feasible and practical. These studies have just begun to reveal the complexity of the genomic landscape of the developing male germ cells. Over 50% of the mouse and rat genome are expressed during testicular development. Among transcripts present in germ cells, 40% - 60% are uncharacterized. A number of genes, and consequently their associated biological pathways, are differentially expressed at different stages of spermatogenesis. Developing male germ cells present a rich repertoire of genetic processes. Tissue-specific as well as spermatogenesis stage-specific alternative splicing of genes exemplifies the complexity of genome expression. In addition to this layer of control, discoveries of abundant presence of antisense transcripts, expressed psuedogenes, non-coding RNAs (ncRNA) including long ncRNAs, microRNAs (miRNAs) and Piwi-interacting RNAs (piRNAs), and retrogenes all point to the presence of multiple layers of expression and functional regulation in male germ cells. It is anticipated that application of systems biology approaches will further our understanding of the regulatory mechanism of spermatogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.