Evidence map›Paper›PMID 19306055›Full record

ArticleClinical and experimental medicine2009

ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas.

Regislaine Valéria Burim, Silvia Aparecida Teixeira, Benedicto Oscar Colli, Fernanda Maris Peria, Luis Fernando Tirapelli, Suely Kazue Nagahashi Marie, Suzana Maria Fleury Malheiros, Sueli Mieko Oba-Shinjo, Alberto Alain Gabbai, Paulo Andrade Lotufo and 1 more

Abstract read
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In one paragraph

Article in Clinical and experimental medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Association of Polymorphisms in Intercellular Adhesion Molecule 1 (ICAM-1) Gene with Cancer Susceptibility: A Meta-Analysis of 14 Case-Control Studies.Medical science monitor : international medical journal of experimental and clinical research · 2016
    Pooled it
  3. Pooled it
  4. Review
  5. The road-map for establishment of a prognostic molecular marker panel in glioma using liquid biopsy: current status and future directions.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Review
  6. Review
  7. Impacts of ICAM-1 gene polymorphisms on urothelial cell carcinoma susceptibility and clinicopathologic characteristics in Taiwan.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
    Article
  8. ICAM-1 +469 A/G polymorphism and cancer risk: a meta-analysis involving 9375 subjects.International journal of clinical and experimental medicine · 2014
    Article
  9. Article
  10. Article
  11. The single nucleotide polymorphism g.1548A >G (K469E) of the ICAM-1 gene is associated with worse prognosis in non-small cell lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012
    Article
  12. Metabolism and brain cancer.Clinics (Sao Paulo, Brazil) · 2011
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Regislaine Valéria BurimDepartment of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, SP 14040-903, Brazil. rvburim@fcfrp.usp.br
Silvia Aparecida Teixeira
Benedicto Oscar Colli
Fernanda Maris Peria
Luis Fernando Tirapelli
Suely Kazue Nagahashi Marie
Suzana Maria Fleury Malheiros
Sueli Mieko Oba-Shinjo
Alberto Alain Gabbai
Paulo Andrade Lotufo
Carlos Gilberto Carlotti-Júnior
Universidade de São Paulo · BRUniversidade Federal de São Paulo · BRHospital Universitário da Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and platelet-endothelial cell adhesion molecule-1 (PECAM-1) play an important role in glioma invasion and angiogenesis. The aim of this study was to investigate whether specific genetic polymorphisms of ICAM-1 and PECAM-1 could be associated with glioma development and progression. Single-nucleotide polymorphism in codon 469 of ICAM-1 and codon 125 of PECAM-1 were examined in 158 patients with astrocytomas and 162 controls using polymerase chain reaction and restriction enzyme analysis. The distribution of PECAM-1 polymorphic genotypes in astrocytomas did not show any significant difference. However, a specific ICAM-1 genotype (G/G, corresponding to Lys469Glu) exhibited higher frequency in grade II astrocytomas compared to controls, grade III, and grade IV astrocytomas; suggesting that this polymorphism could be involved in the development of grade II astrocytomas.

Indexed as

Polymorphism, Single NucleotideAstrocytomaFemaleGenotypeHumansIntercellular Adhesion Molecule-1MaleMiddle AgedPlatelet Endothelial Cell Adhesion Molecule-1Intercellular Adhesion Molecule-1Platelet Endothelial Cell Adhesion Molecule-1

Identifiers

PMID19306055
OpenAlexW2169192440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.