ArticleMammalian genome : official journal of the International Mammalian Genome Society2009
Replication of long-bone length QTL in the F9-F10 LG,SM advanced intercross.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- The genetic basis of neurocranial size and shape across varied lab mouse populations.Journal of anatomy · 2022Article
- Genetic correlations between cartilage regeneration and degeneration reveal an inverse relationship.Osteoarthritis and cartilage · 2020Article
- Fast and flexible linear mixed models for genome-wide genetics.PLoS genetics · 2019Article
- Using whole-genome sequences of the LG/J and SM/J inbred mouse strains to prioritize quantitative trait genes and nucleotides.BMC genomics · 2015Article
- Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico.Frontiers in physiology · 2015Article
- Fine-mapping QTLs in advanced intercross lines and other outbred populations.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- Article
- Exercise and diet affect quantitative trait loci for body weight and composition traits in an advanced intercross population of mice.Physiological genomics · 2012Article
- Heritability of articular cartilage regeneration and its association with ear wound healing in mice.Arthritis and rheumatism · 2012Article
- Article
- Forward genetic approaches to understanding complex behaviors.Current topics in behavioral neurosciences · 2012Review
- Identification of quantitative trait loci influencing skeletal architecture in mice: emergence of Cdh11 as a primary candidate gene regulating femoral morphology.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Evolution of pleiotropy: epistatic interaction pattern supports a mechanistic model underlying variation in genotype-phenotype map.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2011Article
- Genetic factors and diet affect long-bone length in the F34 LG,SM advanced intercross.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Developmental and genetic origins of murine long bone length variation.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2011Article
- Article
- Fine-mapping of muscle weight QTL in LG/J and SM/J intercrosses.Physiological genomics · 2010Article
- Genetic architecture of voluntary exercise in an advanced intercross line of mice.Physiological genomics · 2010Article
- Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Quantitative trait locus (QTL) mapping techniques are frequently used to identify genomic regions associated with variation in phenotypes of interest. However, the F(2) intercross and congenic strain populations usually employed have limited genetic resolution resulting in relatively large confidence intervals that greatly inhibit functional confirmation of statistical results. Here we use the increased resolution of the combined F(9) and F(10) generations (n = 1455) of the LG,SM advanced intercross to fine-map previously identified QTL associated with the lengths of the humerus, ulna, femur, and tibia. We detected 81 QTL affecting long-bone lengths. Of these, 49 were previously identified in the combined F(2)-F(3) population of this intercross, while 32 represent novel contributors to trait variance. Pleiotropy analysis suggests that most QTL affect three to four long bones or serially homologous limb segments. We also identified 72 epistatic interactions involving 38 QTL and 88 novel regions. This analysis shows that using later generations of an advanced intercross greatly facilitates fine-mapping of confidence intervals, resolving three F(2)-F(3) QTL into multiple linked loci and narrowing confidence intervals of other loci, as well as allowing identification of additional QTL. Further characterization of the biological bases of these QTL will help provide a better understanding of the genetics of small variations in long-bone length.
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