Trial reportClinical oral investigations2010
The efficacy of a paste containing Myrtus communis (Myrtle) in the management of recurrent aphthous stomatitis: a randomized controlled trial.
Trial report in Clinical oral investigations, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Herbal extracts in orofacial pain: a systematic review and direct and indirect meta-analysis.Scientific reports · 2024Pooled it
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers).The Cochrane database of systematic reviews · 2012Pooled it
- Urban legends: recurrent aphthous stomatitis.Oral diseases · 2011Pooled it
- Efficacy of a vaginal tablet as a Persian medicine product on vulvovaginal candidiasis: a double-blind, randomised, placebo-controlled trial.Pharmaceutical biology · 2020Trial
- Anti-inflammatory effects of Myrtus communis L. (myrtle): experimental and clinical evidence with an immunological perspective.Inflammopharmacology · 2026Review
- Dietary Antioxidant Index and the Risk of Recurrent Aphthous Stomatitis.International dental journal · 2025Article
- Oral Health and Nutraceutical Agents.International journal of molecular sciences · 2024Review
- Importance of phytotherapy for oral health care and quality of life in adults: A scoping review.Journal of dental sciences · 2024Article
- A systematic review of medicinal plants and herbal products' effectiveness in oral health and dental cure with health promotion approach.Journal of education and health promotion · 2023Review
- How to transfer traditional knowledge about medicinal herbs? or TCM plants: a black box for modern oncologists.Journal of cancer research and clinical oncology · 2021Review
- In Vitro Antibacterial Activity ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Cutaneous Radiation Injuries: Models, Assessment and Treatments.Radiation research · 2020Article
- How to bridge the gap? European medical plants used for treating oral mucositis: on the search for evidence.Journal of cancer research and clinical oncology · 2020Article
- Phytocompounds vs. Dental Plaque Bacteria:Frontiers in microbiology · 2020Article
- An Evidence-Based Review of Medicinal Plants Used for the Treatment of Vaginitis byGalen medical journal · 2019Review
- Antioxidant Activity ofMedicines (Basel, Switzerland) · 2018Review
- Phytoniosome: a Novel Drug Delivery for Myrtle Extract.Iranian journal of pharmaceutical research : IJPR · 2018Article
- Formulation and Optimization of Oral Mucoadhesive Patches of Myrtus Communis by Box Behnken Design.Advanced pharmaceutical bulletin · 2017Article
- The Most Common Herbs to Cure the Most Common Oral Disease: Stomatitis Recurrent Aphthous Ulcer (RAU).Iranian Red Crescent medical journal · 2016Review
- Treatment of recurrent aphthous stomatitis. A literature review.Journal of clinical and experimental dentistry · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recurrent aphthous stomatitis (RAS) is a common, painful, and ulcerative disorder of the oral cavity with unknown etiology. Treatment is a highly controversial topic. The aim of this study was to evaluate the clinical efficacy of a novel paste containing Myrtus communis (Myrtle) in the treatment of recurrent aphthous stomatitis. Myrtle is a particular herb used in some cultures as treatment for mouth ulcers. The study was a randomized, double-blind, controlled before-after clinical trial. Forty-five patients with RAS randomly participated in this study. The subjects were treated with placebo paste and myrtle oral paste in two consecutive episodes. The paste was applied by subjects themselves four times a day for 6 days. Five parameters (size change, pain scale, erythema and exudation level, oral health impact profile, and patient overall assessment of their treatment) were recorded both before (baseline) and during each episodes of treatment (on the morning of days 2, 4, and 6). There were no statistically significant differences between baseline parameters (p > 0.05). The data indicated a statistically significant reduction of ulcer size (p < 0.001), pain severity (p < 0.05), and erythema and exudation level (p < 0.001). Oral Health Impact Profile improved significantly in the treatment group (p < 0.001). Patient overall assessment of their treatment improved after applying paste containing myrtle (p < 0.05). No side effects were reported. This study has shown myrtle to be effective in decreasing the size of ulcers, pain severity and the level of erythema and exudation, and improving the quality of life in patients who suffer from RAS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.