ArticleDiabetologia2009
Ambulatory blood pressure measurements are related to albumin excretion and are predictive for risk of microalbuminuria in young people with type 1 diabetes.
Article in Diabetologia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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28 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- ISPAD Clinical Practice Consensus Guidelines 2018: Microvascular and macrovascular complications in children and adolescents.Pediatric diabetes · 2018Guideline
- Diastolic Blood Pressure Abnormalities and Their Relationship with Glycemic Control in Pediatric Type 1 Diabetes.Journal of clinical medicine · 2025Article
- Clinic, Ambulatory and Home Blood Pressure Monitoring for Metabolic Syndrome: Time to Change the Definition?Medicina (Kaunas, Lithuania) · 2025Article
- Reduced methylation correlates with diabetic nephropathy risk in type 1 diabetes.The Journal of clinical investigation · 2023Article
- Is there a characteristic pattern of ambulatory blood pressure profile in type 1 diabetic children and adolescents?Annals of pediatric endocrinology & metabolism · 2022Article
- Effects of circadian blood pressure patterns on development of microvascular complications in pediatric patients with type 1 diabetes mellitus.Annals of pediatric endocrinology & metabolism · 2022Article
- Evaluation of early retinal vascular changes by optical coherence tomography angiography in children with type 1 diabetes mellitus without diabetic retinopathy.International ophthalmology · 2022Article
- Lowest nocturnal systolic blood pressure is related to heavy proteinuria and outcomes in elderly patients with chronic kidney disease.Scientific reports · 2021Article
- Evidence of Early Diabetic Nephropathy in Pediatric Type 1 Diabetes.Frontiers in endocrinology · 2021Article
- High frequency of nocturnal hypertension in lupus nephritis: should ABPM be implemented in usual practice?Clinical rheumatology · 2020Article
- The renal resistive index as a new complementary tool to predict microvascular diabetic complications in children and adolescents: a groundbreaking finding.Annals of translational medicine · 2019Review
- A new strategy for vascular complications in young people with type 1 diabetes mellitus.Nature reviews. Endocrinology · 2019Review
- Blood Pressure Variability and Autonomic Dysfunction.Current diabetes reports · 2018Review
- Clustering of cardio-metabolic risk factors in parents of adolescents with type 1 diabetes and microalbuminuria.Pediatric diabetes · 2017Article
- The Genetic Landscape of Renal Complications in Type 1 Diabetes.Journal of the American Society of Nephrology : JASN · 2017Article
- Early changes in cardiovascular structure and function in adolescents with type 1 diabetes.Cardiovascular diabetology · 2016Observational
- Higher dietary salt intake is associated with microalbuminuria, but not with retinopathy in individuals with type 1 diabetes: the EURODIAB Prospective Complications Study.Diabetologia · 2014Article
- Transition from pediatric to adult care. eight years after the transition from pediatric to adult diabetes care: metabolic control, complications and associated diseases.Journal of endocrinological investigation · 2014Article
- Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes.Diabetologia · 2014Article
- Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients.Diabetologia · 2014Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
aims/hypothesisThe relationship between BP and microalbuminuria in young people with type 1 diabetes is not completely clear. As microalbuminuria is preceded by a gradual rise in albumin excretion within the normal range, we hypothesised that ambulatory BP (ABP) may be closely related to albumin excretion and progression to microalbuminuria.
methodsABP monitoring (ABPM) was performed in 509 young people with type 1 diabetes (age median [range]: 15.7 [10.7-22.6] years) followed with annual assessments of three early morning urinary albumin:creatinine ratios (ACRs) and HbA(1c). Systolic BP (SBP) and diastolic BP (DBP) and the nocturnal fall in BP were analysed in relation to ACR.
resultsAll ABPM variables were significantly related to baseline log(10) ACR (p < 0.001). After the ABPM evaluation, 287 patients were followed for a median of 2.2 (1.0-5.5) years. ABP at baseline was independently related to mean ACR during follow-up. Nineteen initially normoalbuminuric patients developed microalbuminuria after 2.0 (0.2-4.0) years and their baseline daytime DBP was higher than in normoalbuminuric patients (p < 0.001). After adjusting for baseline ACR and HbA(1c), there was an 11% increased risk of microalbuminuria for each 1 mmHg increase in daytime DBP. Forty-eight per cent of patients were non-dippers for SBP and 60% for DBP; however, ACR was not different between dippers and non-dippers and there were no differences in the nocturnal fall in BP between normoalbuminuric and future microalbuminuric patients. CONCLUSIONS/
interpretationIn this cohort of young people with type 1 diabetes, ABP was significantly related to ACR, and daytime DBP was independently associated with progression to microalbuminuria. Increasing albumin excretion, even in the normal range, may be associated with parallel rises in BP.
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