ArticlePlant physiology2009
Phospholipase D activation is an early component of the salicylic acid signaling pathway in Arabidopsis cell suspensions.
Article in Plant physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 73 citations in OpenAlex.
- Phospholipid Signaling in Crop Plants: A Field to Explore.Plants (Basel, Switzerland) · 2024Article
- DIACYLGLYCEROL KINASE 5 participates in flagellin-induced signaling in Arabidopsis.Plant physiology · 2022Article
- Phosphatidic Acid in Plant Hormonal Signaling: From Target Proteins to Membrane Conformations.International journal of molecular sciences · 2022Review
- Article
- Phospholipid Signaling Is a Component of the Salicylic Acid Response in Plant Cell Suspension Cultures.International journal of molecular sciences · 2020Review
- Deciphering the Binding of Salicylic Acid toInternational journal of molecular sciences · 2020Article
- Arabidopsis GDSL1 overexpression enhances rapeseed Sclerotinia sclerotiorum resistance and the functional identification of its homolog in Brassica napus.Plant biotechnology journal · 2020Article
- Identification of salicylic acid-independent responses in an Arabidopsis phosphatidylinositol 4-kinase beta double mutant.Annals of botany · 2020Article
- Salicylic Acid Binding Proteins (SABPs): The Hidden Forefront of Salicylic Acid Signalling.International journal of molecular sciences · 2019Review
- The SCOOP12 peptide regulates defense response and root elongation in Arabidopsis thaliana.Journal of experimental botany · 2019Article
- Biochemical and Genetic Interactions of Phospholipase D Alpha 1 and Mitogen-Activated Protein Kinase 3 Affect Arabidopsis Stress Response.Frontiers in plant science · 2019Article
- The Arabidopsis thaliana non-specific phospholipase C2 is involved in the response to Pseudomonas syringae attack.Annals of botany · 2018Article
- Constitutive cyclic GMP accumulation in Arabidopsis thaliana compromises systemic acquired resistance induced by an avirulent pathogen by modulating local signals.Scientific reports · 2016Article
- Functional diversity of jasmonates in rice.Rice (New York, N.Y.) · 2015Article
- Phospholipase D and phosphatidic acid in plant defence response: from protein-protein and lipid-protein interactions to hormone signalling.Journal of experimental botany · 2015Review
- Phospholipase D affects translocation of NPR1 to the nucleus in Arabidopsis thaliana.Frontiers in plant science · 2015Article
- Importance of phosphoinositide-dependent signaling pathways in the control of gene expression in resting cells and in response to phytohormones.Plant signaling & behavior · 2015Article
- Positive effects of salicylic acid pretreatment on the composition of flax plastidial membrane lipids under cadmium stress.Environmental science and pollution research international · 2015Article
- The pepper patatin-like phospholipase CaPLP1 functions in plant cell death and defense signaling.Plant molecular biology · 2014Article
- Salicylic acid modulates levels of phosphoinositide dependent-phospholipase C substrates and products to remodel the Arabidopsis suspension cell transcriptome.Frontiers in plant science · 2014Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salicylic acid (SA) plays a central role in defense against pathogen attack, as well as in germination, flowering, senescence, and the acquisition of thermotolerance. In this report we investigate the involvement of phospholipase D (PLD) in the SA signaling pathway. In presence of exogenous primary alcohols, the production of phosphatidic acid by PLD is diverted toward the formation of phosphatidylalcohols through a reaction called transphosphatidylation. By in vivo metabolic phospholipid labeling with (33)P(i), PLD activity was found to be induced 45 min after addition of SA. We show that incubation of Arabidopsis (Arabidopsis thaliana) cell suspensions with primary alcohols inhibited the induction of two SA-responsive genes, PATHOGENESIS-RELATED1 and WRKY38, in a dose-dependent manner. This inhibitory effect was more pronounced when the primary alcohols were more hydrophobic. Secondary or tertiary alcohols had no inhibitory effect. These results provide compelling arguments for PLD activity being upstream of the induction of these genes by SA. A subsequent study of n-butanol effects on the SA-responsive transcriptome identified 1,327 genes differentially expressed upon SA treatment. Strikingly, the SA response of 380 of these genes was inhibited by n-butanol but not by tert-butanol. A detailed analysis of the regulation of these genes showed that PLD could act both positively and negatively, either on gene induction or gene repression. The overlap with the previously described phosphatidylinositol-4-kinase pathway is discussed.
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