ArticlePlant physiology2009
The synthetic elicitor 3,5-dichloroanthranilic acid induces NPR1-dependent and NPR1-independent mechanisms of disease resistance in Arabidopsis.
Article in Plant physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 82 citations in OpenAlex.
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- Decursin, Identified via High-Throughput Chemical Screening, Enhances Plant Disease Resistance via Two Independent Mechanisms.Molecular plant pathology · 2025Article
- Chemical Biology Meets Metabolomics: The Response of Barley Seedlings to 3,5-Dichloroanthranilic Acid, a Resistance Inducer.Molecules (Basel, Switzerland) · 2025Article
- The Past, Present, and Future of Plant Activators Targeting the Salicylic Acid Signaling Pathway.Genes · 2024Review
- The Emerging Role ofPlants (Basel, Switzerland) · 2024Review
- Novel in silico screening system for plant defense activators using deep learning-based prediction of reactive oxygen species accumulation.Plant methods · 2023Article
- Article
- Plant Defense Responses to a Novel Plant Elicitor Candidate LY5-24-2.International journal of molecular sciences · 2022Article
- Carbon nanotube biocompatibility in plants is determined by their surface chemistry.Journal of nanobiotechnology · 2021Article
- Metabolic and Transcriptomic Profiling ofFrontiers in plant science · 2021Article
- Synthetic Mono-Rhamnolipids Display Direct Antifungal Effects and Trigger an Innate Immune Response in Tomato againstMolecules (Basel, Switzerland) · 2020Article
- The Use of PTI-Marker Genes to Identify Novel Compounds that Establish Induced Resistance in Rice.International journal of molecular sciences · 2020Article
- New QTLs for Spot Blotch Disease Resistance in Wheat (Frontiers in genetics · 2020Article
- A novel Arabidopsis pathosystem reveals cooperation of multiple hormonal response-pathways in host resistance against the global crop destroyer Macrophomina phaseolina.Scientific reports · 2019Article
- Plant chemical genetics reveals colistin sulphate as a SA and NPR1-independent PR1 inducer functioning via a p38-like kinase pathway.Scientific reports · 2019Article
- A chemical screen identifies two novel small compounds that alter Arabidopsis thaliana pollen tube growth.BMC plant biology · 2019Article
- A Disease Resistance Elicitor Laminarin Enhances Tea Defense against a Piercing Herbivore Empoasca (Matsumurasca) onukii Matsuda.Scientific reports · 2019Article
- Different Pathogen Defense Strategies inCells · 2018Review
- Synthetic Rhamnolipid Bolaforms trigger an innate immune response in Arabidopsis thaliana.Scientific reports · 2018Article
- Optimizing the Use of a Liquid Handling Robot to Conduct a High Throughput Forward Chemical Genetics Screen of Arabidopsis thaliana.Journal of visualized experiments : JoVE · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune responses of Arabidopsis (Arabidopsis thaliana) are at least partially mediated by coordinated transcriptional up-regulation of plant defense genes, such as the Late/sustained Up-regulation in Response to Hyaloperonospora parasitica (LURP) cluster. We found a defined region in the promoter of the LURP member CaBP22 to be important for this response. Using a CaBP22 promoter-reporter fusion, we have established a robust and specific high-throughput screening system for synthetic defense elicitors that can be used to trigger defined subsets of plant immune responses. Screening a collection of 42,000 diversity-oriented molecules, we identified 114 candidate LURP inducers. One representative, 3,5-dichloroanthranilic acid (DCA), efficiently induced defense reactions to the phytopathogens H. parasitica and Pseudomonas syringae. In contrast to known salicylic acid analogs, such as 2,6-dichloroisonicotinic acid (INA), which exhibit a long-lasting defense-inducing activity and are fully dependent on the transcriptional cofactor NPR1 (for Nonexpresser of Pathogenesis-Related genes1), DCA acts transiently and is only partially dependent on NPR1. Microarray analyses revealed a cluster of 142 DCA- and INA-responsive genes that show a pattern of differential expression coinciding with the kinetics of DCA-mediated disease resistance. These ACID genes (for Associated with Chemically Induced Defense) constitute a core gene set associated with chemically induced disease resistance, many of which appear to encode components of the natural immune system of Arabidopsis.
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