ArticleHuman molecular genetics2009
Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.
Article in Human molecular genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 8 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 8 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Six polymorphisms in the lncRNA H19 gene and the risk of cancer: a systematic review and meta-analysis.BMC cancer · 2023Pooled it
- The association between single nucleotide polymorphisms and ovarian cancer risk: A systematic review and network meta-analysis.Cancer medicine · 2023Pooled it
- Pooled it
- Pooled it
- Association between genetic polymorphisms of long noncoding RNA H19 and cancer risk: a meta-analysis.Journal of genetics · 2019Pooled it
- Significant association between lncRNA H19 polymorphisms and cancer susceptibility: a meta-analysis.Oncotarget · 2017Pooled it
- The HOTAIR, PRNCR1 and POLR2E polymorphisms are associated with cancer risk: a meta-analysis.Oncotarget · 2017Pooled it
- Quantitative assessment of polymorphisms in H19 lncRNA and cancer risk: a meta-analysis of 13,392 cases and 18,893 controls.Oncotarget · 2016Pooled it
- Gene polymorphisms ofJournal of Cancer · 2024Article
- Neurexophilin 4 is a prognostic biomarker correlated with immune infiltration in bladder cancer.Bioengineered · 2022Article
- Increased Expression of NXPH4 Correlates with Immune Cell Infiltration and Unfavorable Prognosis in Hepatocellular Carcinoma.Journal of oncology · 2022Article
- Low-penetrance susceptibility variants and postmenopausal oestrogen receptor positive breast cancer.Journal of genetics · 2020Article
- Association of lncRNAGenes · 2019Article
- Comparisons of gene coexpression network modules in breast cancer and ovarian cancer.BMC systems biology · 2018Article
- ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas.Gynecologic oncology · 2013Article
- No association between ovarian cancer susceptibility variants and breast cancer risk among Chinese women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- Calling amplified haplotypes in next generation tumor sequence data.Genome research · 2012Article
- Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients.Clinical cancer research : an official journal of the American Association for Cancer Research · 2011Article
- Article
- Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk.Human molecular genetics · 2011Article
Corrections and comments
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Authors and funding
52 authors at 18 institutions in 6 countries.
Funding
Abstract
Because both ovarian and breast cancer are hormone-related and are known to have some predisposition genes in common, we evaluated 11 of the most significant hits (six with confirmed associations with breast cancer) from the breast cancer genome-wide association study for association with invasive ovarian cancer. Eleven SNPs were initially genotyped in 2927 invasive ovarian cancer cases and 4143 controls from six ovarian cancer case-control studies. Genotype frequencies in cases and controls were compared using a likelihood ratio test in a logistic regression model stratified by study. Initially, three SNPs (rs2107425 in MRPL23, rs7313833 in PTHLH, rs3803662 in TNRC9) were weakly associated with ovarian cancer risk and one SNP (rs4954956 in NXPH2) was associated with serous ovarian cancer in non-Hispanic white subjects (P-trend < 0.1). These four SNPs were then genotyped in an additional 4060 cases and 6308 controls from eight independent studies. Only rs4954956 was significantly associated with ovarian cancer risk both in the replication study and in combined analyses. This association was stronger for the serous histological subtype [per minor allele odds ratio (OR) 1.07 95% CI 1.01-1.13, P-trend = 0.02 for all types of ovarian cancer and OR 1.14 95% CI 1.07-1.22, P-trend = 0.00017 for serous ovarian cancer]. In conclusion, we found that rs4954956 was associated with increased ovarian cancer risk, particularly for serous ovarian cancer. However, none of the six confirmed breast cancer susceptibility variants we tested was associated with ovarian cancer risk. Further work will be needed to identify the causal variant associated with rs4954956 or elucidate its function.
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