ArticleHuman molecular genetics2009
Admixture mapping of quantitative trait loci for blood lipids in African-Americans.
Article in Human molecular genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: the Family Blood Pressure Program.Atherosclerosis · 2014Pooled it
- Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium.Human molecular genetics · 2011Pooled it
- Genome-wide association study of blood lipids in Indians confirms universality of established variants.Journal of human genetics · 2019Article
- Comparison of Genetic and Self-Identified Ancestry in Modeling Intracerebral Hemorrhage Risk.Frontiers in neurology · 2018Article
- Local Ancestry and Clinical Cardiovascular Events Among African Americans From the Atherosclerosis Risk in Communities Study.Journal of the American Heart Association · 2017Article
- Variants for HDL-C, LDL-C, and triglycerides identified from admixture mapping and fine-mapping analysis in African American families.Circulation. Cardiovascular genetics · 2015Article
- Extensive copy number variations in admixed Indian population of African ancestry: potential involvement in adaptation.Genome biology and evolution · 2014Article
- Cardiovascular risk in Gullah African Americans with high familial risk of type 2 diabetes mellitus: project SuGAR.Southern medical journal · 2014Article
- Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations.Genome medicine · 2014Article
- Skeletal muscle adiposity is associated with serum lipid and lipoprotein levels in Afro-Caribbean men.Obesity (Silver Spring, Md.) · 2013Article
- Generalized admixture mapping for complex traits.G3 (Bethesda, Md.) · 2013Article
- Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.American journal of human genetics · 2013Article
- Variants in CXADR and F2RL1 are associated with blood pressure and obesity in African-Americans in regions identified through admixture mapping.Journal of hypertension · 2012Article
- Power comparison of admixture mapping and direct association analysis in genome-wide association studies.Genetic epidemiology · 2012Article
- The role of PRKCH gene variants in coronary artery disease in a Chinese population.Molecular biology reports · 2012Article
- Recent admixture in an Indian population of African ancestry.American journal of human genetics · 2011Article
- A genome-wide admixture scan for ancestry-linked genes predisposing to sarcoidosis in African-Americans.Genes and immunity · 2011Article
- Differential endothelial cell gene expression by African Americans versus Caucasian Americans: a possible contribution to health disparity in vascular disease and cancer.BMC medicine · 2011Article
- Admixture mapping of end stage kidney disease genetic susceptibility using estimated mutual information ancestry informative markers.BMC medical genomics · 2010Article
- The role of European genetic admixture in the etiology of the insulin resistance syndrome in children: are the effects mediated by fat accumulation?The Journal of pediatrics · 2010Article
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Authors and funding
10 authors at 9 institutions in 2 countries.
Funding
Abstract
Blood lipid levels, including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG), are highly heritable traits and major risk factors for atherosclerotic cardiovascular disease (CVD). Using individual ancestry estimates at marker locations across the genome, we present a novel quantitative admixture mapping analysis of all three lipid traits in a large sample of African-Americans from the Family Blood Pressure Program. Regression analysis was performed with both total and marker-location-specific European ancestry as explanatory variables, along with demographic covariates. Robust permutation analysis was used to assess statistical significance. Overall European ancestry was significantly correlated with HDL-C (negatively) and TG (positively), but not with LDL-C. We found strong evidence for a novel locus underlying HDL-C on chromosome 8q, which correlated negatively with European ancestry (P = .0014); the same location also showed positive correlation of European ancestry with TG levels. A region on chromosome 14q also showed significant negative correlation between HDL-C levels and European ancestry. On chromosome 15q, a suggestive negative correlation of European ancestry with TG and positive correlation with HDL-C was observed. Results with LDL-C were less significant overall. We also found significant evidence for genome-wide ancestry effects underlying the joint distribution of HDL-C and TG, not fully explained by the locus on chromosome 8. Our results are consistent with a genetic contribution to and may explain the healthier HDL-C and TG profiles found in Blacks versus Whites. The identified regions provide locations for follow-up studies of genetic variants underlying lipid variation in African-Americans and possibly other populations.
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