Evidence map›Paper›PMID 19303823›Full record

ReviewJournal of chromatography. B, Analytical technologies in the biomedical and life sciences2009

Discovering novel brain lipids by liquid chromatography/tandem mass spectrometry.

Ziqiang Guan

Abstract readEvaluation StudyReview
In one paragraph

Review in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. The foundations and development of lipidomics.Journal of lipid research · 2022
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Genetic defects in dolichol metabolism.Journal of inherited metabolic disease · 2015
    Review
  10. A systematic survey of lipids across mouse tissues.American journal of physiology. Endocrinology and metabolism · 2014
    Article
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Ziqiang GuanDepartment of Biochemistry, Duke University Medical Center, 240 Nanaline Duke, P.O. Box 3711, Durham, NC 27710, USA. zguan@biochem.duke.edu
Duke University · US

Funding

STEROL LIPIDSU54GM069338 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DENNIS, EDWARD A · 2003 to 2013
$72.2M
NIGMS NIH HHS GM069338NIGMS NIH HHS U54 GM069338
6 · The paper itself

Abstract

Discovery and structural elucidation of novel brain lipids hold great promise in revealing new lipid functions in the brain and in understanding the biochemical mechanisms underlying brain physiology and pathology. The revived interests in searching for novel brain lipids have been stimulated by the expanding knowledge of the roles of lipids in brain functions, lipids acting as signaling molecules, and the advent of lipidomics enabled by the advances in mass spectrometry (MS) and liquid chromatography (LC). The identification and characterization of two classes of novel lipids from the brain are reviewed here: N-acyl phosphatidylserine (N-acyl-PS) and dolichoic acid (Dol-CA). The identification of these lipids benefited from the use of efficient lipid fractionation and separation techniques and highly sensitive, high-resolution tandem MS.

Indexed as

Brain ChemistryAnimalsBrainChromatography, LiquidHumansLipid MetabolismLipidsTandem Mass SpectrometryLipids

Identifiers

PMID19303823
PMCPMC2723173
OpenAlexW1966740725

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.