ArticleMolecular and cellular neurosciences2009
Altered LARK expression perturbs development and physiology of the Drosophila PDF clock neurons.
Article in Molecular and cellular neurosciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Blue light restores functional circadian clocks in eyeless cave spiders.Science advances · 2025Article
- Bmlark is essential for embryonic development.BMC genomics · 2024Article
- Post-transcriptional modulators and mediators of the circadian clock.Chronobiology international · 2021Review
- Identification of LARK as a novel and conserved G-quadruplex binding protein in invertebrates and vertebrates.Nucleic acids research · 2019Article
- Translational regulation of the DOUBLETIME/CKIδ/ε kinase by LARK contributes to circadian period modulation.PLoS genetics · 2014Article
- Brain proteomics of Anopheles gambiae.Omics : a journal of integrative biology · 2014Article
- NAT1/DAP5/p97 and atypical translational control in the Drosophila Circadian Oscillator.Genetics · 2012Article
- Speed control: cogs and gears that drive the circadian clock.Trends in neurosciences · 2012Review
- Cellular requirements for LARK in the Drosophila circadian system.Journal of biological rhythms · 2012Article
- Fragile X mental retardation protein is required for programmed cell death and clearance of developmentally-transient peptidergic neurons.Developmental biology · 2011Article
- Post-transcriptional control of circadian rhythms.Journal of cell science · 2011Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The LARK RNA-binding protein (RBP) has well documented roles in the circadian systems of Drosophila and mammals. Recent studies have demonstrated that the Drosophila LARK RBP is associated with many mRNA targets, in vivo, including those that regulate either neurophysiology or development of the nervous system. In the present study, we have employed conditional expression techniques to distinguish developmental and physiological functions of LARK for a defined class of neurons: the Pigment-Dispersing Factor (PDF)-containing LNv clock neurons. We found that increased LARK expression during development dramatically alters the small LNv class of neurons with no obvious effects on the large LNv cells. Conversely, conditional expression of LARK at the adult stage results in altered clock protein rhythms and circadian locomotor activity, even though neural morphology is normal in such animals. Electrophysiological analyses at the larval neuromuscular junction indicate a role for LARK in regulating neuronal excitability. Altogether, our results demonstrate that LARK activity is critical for neuronal development and physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.