ArticlePlacenta2009
Human placental adenosine receptor expression is elevated in preeclampsia and hypoxia increases expression of the A2A receptor.
Article in Placenta, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Potential role of A2B adenosine receptors on proliferation/migration of fetal endothelium derived from preeclamptic pregnancies.BioMed research international · 2014Trial
- Placental SNV rs8192446 in theFrontiers in physiology · 2026Article
- Dynamic shifts in trophoblast nucleos(t)ide metabolism, transport, and adenosine signaling during gestation and preterm birth.Scientific reports · 2025Article
- Article
- Article
- CD39 abrogates platelet-derived factors induced IL-1β expression in the human placenta.Frontiers in cell and developmental biology · 2023Article
- Adenosine kinase: An epigenetic modulator in development and disease.Neurochemistry international · 2021Review
- Network analysis of the left anterior descending coronary arteries in swim-trained rats by an in situ video microscopic technique.Biology of sex differences · 2021Article
- Article
- Purinergic Signalling: Therapeutic Developments.Frontiers in pharmacology · 2017Review
- Purinergic signalling in the reproductive system in health and disease.Purinergic signalling · 2014Review
- Adenosine A2B receptors induce proliferation, invasion and activation of cAMP response element binding protein (CREB) in trophoblast cells.BMC pregnancy and childbirth · 2014Article
- Article
- Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming.Frontiers in pharmacology · 2014Review
- Impaired A2A adenosine receptor/nitric oxide/VEGF signaling pathway in fetal endothelium during late- and early-onset preeclampsia.Purinergic signalling · 2013Article
- The placenta in preeclampsia.Pregnancy hypertension · 2012Article
- Caffeine reduces 11β-hydroxysteroid dehydrogenase type 2 expression in human trophoblast cells through the adenosine A(2B) receptor.PloS one · 2012Article
- Adenosine A₂a receptors and O₂ sensing in development.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Review
- Natural killer cell-triggered vascular transformation: maternal care before birth?Cellular & molecular immunology · 2011Review
- Regulation of sFlt-1 and VEGF secretion by adenosine under hypoxic conditions in rat placental villous explants.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Placental hypoxia as a result of impaired trophoblast invasion is suggested to be involved in the pathophysiology of preeclampsia. Hypoxia is a potent stimulus for the release of adenosine, and the actions of adenosine are mediated through four adenosine receptors, A(1), A(2A), A(2B) and A(3). We investigated the presence, distribution and expression of adenosine receptor subtypes in the human placenta, the expression of the adenosine receptors in placentas from pregnancies complicated by preeclampsia, small for gestational age (SGA) infants and uncomplicated pregnancies, and the effect of hypoxia on placental adenosine receptor expression. Immunofluorescent microscopy localized A(1), A(2A), A(2B) and A(3) adenosine receptors to the syncytiotrophoblast, endothelial cells and myofibroblasts within the human placenta. Adenosine receptor protein and message expression levels were significantly higher in placentas from preeclamptic pregnancies with or without SGA infants, but not different in pregnancies with SGA infants alone. In vitro exposure of placental villous explants to hypoxia (2% oxygen) increased the expression of A(2A) adenosine receptor 50%. These data indicate that all four known adenosine receptors are expressed in the human placenta and adenosine receptor expression is significantly higher in pregnancies complicated by preeclampsia. These data are consistent with the hypothesis that differences in placental adenosine receptors may contribute to alterations in placental function in preeclampsia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.