Evidence map›Paper›PMID 19303038›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2009

A designer biomimetic vector with a chimeric architecture for targeted gene transfer.

Yuhua Wang, Sriramchandra Sastry Mangipudi, Brenda F Canine, Arash Hatefi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 49 citations in OpenAlex.

  1. Peptide-Assisted Nucleic Acid Delivery Systems on the Rise.International journal of molecular sciences · 2021
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Functional peptides for siRNA delivery.Advanced drug delivery reviews · 2017
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Frontiers in Suicide Gene Therapy of Cancer.Journal of genetic syndromes & gene therapy · 2012
    Article
  13. Cathepsin B-sensitive polymers for compartment-specific degradation and nucleic acid release.Journal of controlled release : official journal of the Controlled Release Society · 2012
    Article
  14. Development of targeted recombinant polymers that can deliver siRNA to the cytoplasm and plasmid DNA to the cell nucleus.Journal of controlled release : official journal of the Controlled Release Society · 2011
    Article
  15. HSV-TK/GCV cancer suicide gene therapy by a designed recombinant multifunctional vector.Nanomedicine : nanotechnology, biology, and medicine · 2011
    Article
  16. Review
  17. Biosynthesis and characterization of a novel genetically engineered polymer for targeted gene transfer to cancer cells.Journal of controlled release : official journal of the Controlled Release Society · 2009
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yuhua WangDepartment of Pharmaceutical Sciences, Center for Integrated Biotechnology, Washington State University, P.O. Box 646534, Pullman, WA 99164, USA.
Sriramchandra Sastry Mangipudi
Brenda F Canine
Arash Hatefi
Washington State University · US

Funding

TRAINING IN BIOTECHNOLOGY: EMPHASIS ON PROTEIN CHEMISTRYT32GM008336 · NIGMS · WASHINGTON STATE UNIVERSITY · PI CALL, DOUGLAS R. · 1989 to 2023
$8.9M
NIGMS NIH HHS T32 GM008336
6 · The paper itself

Abstract

Designer biomimetic vectors are genetically engineered biomacromolecules that are designed to mimic viral characteristics in order to overcome the cellular barriers associated with the targeted gene transfer. The vector in this study was genetically engineered to contain at precise locations: a) four tandem repeating units of N-terminal domain of histone H2A to condense DNA into stable nanosize particles suitable for cellular uptake, b) a model targeting motif to target HER2 and enhance internalization of nanoparticles, and c) a pH-responsive synthetic fusogenic peptide to disrupt endosome membranes and promote escape of the nanoparticles into the cytosol. The results demonstrate that a fully functional, multi-domain, designer vector can be engineered to target cells with high specificity, overcome the biological barriers associated with targeted gene transfer, and mediate efficient gene transfer.

Indexed as

BiomimeticsGenetic EngineeringGene Transfer TechniquesAnimalsCell SurvivalChloroquineDNAEndosomesErb-b2 Receptor Tyrosine KinasesGenetic TherapyGenetic VectorsGreen Fluorescent ProteinsHeLa CellsHistonesHumansHydrogen-Ion Concentrationbafilomycin A1ChloroquineDNAenhanced green fluorescent proteinErb-b2 Receptor Tyrosine KinasesGALA peptideGreen Fluorescent ProteinsHistonesMacrolidesPeptides

Identifiers

PMID19303038
PMCPMC2925643
OpenAlexW2021038659

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.