ArticleJournal of pediatric surgery2009
Cholangiocyte secretion of chemokines in experimental biliary atresia.
Article in Journal of pediatric surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Exploring causality with biliary atresia at different levels: two-sample Mendelian randomization study.World journal of pediatric surgery · 2024Article
- Deletion of Interferon Lambda Receptor Elucidates Susceptibility to the Murine Model of Biliary Atresia.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2023Article
- Systems Analysis of Biliary Atresia Through Integration of High-Throughput Biological Data.Frontiers in physiology · 2020Article
- Innate Immunity and Pathogenesis of Biliary Atresia.Frontiers in immunology · 2020Review
- Cell-specific regulatory effects of CXCR2 on cholestatic liver injury.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- MicroRNA-155 modulates bile duct inflammation by targeting the suppressor of cytokine signaling 1 in biliary atresia.Pediatric research · 2017Article
- Functional and structural features of cholangiocytes in health and disease.Cellular and molecular gastroenterology and hepatology · 2015Article
- Pathogenesis of biliary atresia: defining biology to understand clinical phenotypes.Nature reviews. Gastroenterology & hepatology · 2015Review
- MicroRNAs and benign biliary tract diseases.Seminars in liver disease · 2015Review
- Rotavirus Infects Human Biliary Epithelial Cells and Stimulates Secretion of Cytokines IL-6 and IL-8 via MAPK Pathway.BioMed research international · 2015Article
- MCP-1 downregulates MMP-9 export via vesicular redistribution to lysosomes in rat portal fibroblasts.Physiological reports · 2014Article
- Expansion of prominin-1-expressing cells in association with fibrosis of biliary atresia.Hepatology (Baltimore, Md.) · 2014Article
- Aetiology of biliary atresia: what is actually known?Orphanet journal of rare diseases · 2013Review
- Rotavirus replication in the cholangiocyte mediates the temporal dependence of murine biliary atresia.PloS one · 2013Article
- Advances in cholangiocyte immunobiology.American journal of physiology. Gastrointestinal and liver physiology · 2012Review
- Rotavirus infection of human cholangiocytes parallels the murine model of biliary atresia.The Journal of surgical research · 2012Article
- Transcriptomic and physiological responses to fishmeal substitution with plant proteins in formulated feed in farmed Atlantic salmon (Salmo salar).BMC genomics · 2012Article
- Dendritic cells regulate natural killer cell activation and epithelial injury in experimental biliary atresia.Science translational medicine · 2011Article
- Cholangiocyte N-Ras protein mediates lipopolysaccharide-induced interleukin 6 secretion and proliferation.The Journal of biological chemistry · 2011Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledBiliary atresia (BA) is a disease of the newborn that results in obstruction of the biliary tree. The cause of BA remains unknown; however, recent studies using the murine model of biliary atresia have found that rotavirus infection of the biliary epithelial cell (cholangiocyte) triggers an inflammatory response. We hypothesized that rotavirus infection of cholangiocytes results in the release of chemokines, important mediators of the host immune response.
methodsIn vivo, Balb/c pups were injected with rhesus rotavirus (RRV) or saline, and, their extrahepatic bile ducts were microdissected 2, 5, 7, and 14 days after injection. Next, an immortalized cholangiocyte cell line (mCl) was incubated with RRV or serum-free media. Qualitative and quantitative chemokine assessment was performed using enzyme-linked immunosorbent assay, polymerase chain reaction, and immunohistochemistry.
resultsIn vivo, increased levels of the chemokines macrophage inflammatory protein 2, monocyte chemotactic protein 1, KC and Regulated upon Activation, Normal T Expressed and Secreted were found in RRV-infected murine bile ducts. In vitro, infected mCl cells produced increasing amounts of these same chemokines in relation to dose and time.
conclusionThese novel results suggest that chemokine expression by RRV-infected cholangiocytes may trigger a host inflammatory process that causes bile duct obstruction. Understanding how viral infection initiates this response may shed light on the pathogenesis of biliary atresia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.