ReviewCurrent psychiatry reports2009
The genetics of childhood-onset schizophrenia: when madness strikes the prepubescent.
Review in Current psychiatry reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 4 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Predictors of treatment resistant schizophrenia: a systematic review of prospective observational studies.Psychological medicine · 2021Pooled it
- Childhood-Onset Schizophrenia: A Systematic Overview of Its Genetic Heterogeneity From Classical Studies to the Genomic Era.Frontiers in genetics · 2019Pooled it
- Genetic association analysis of ITGB3 polymorphisms with age at onset of schizophrenia.Journal of molecular neuroscience : MN · 2013Pooled it
- Microduplications disrupting the MYT1L gene (2p25.3) are associated with schizophrenia.Psychiatric genetics · 2012Pooled it
- Strong Treatment Response and High Maintenance Rates of Clozapine in Childhood-Onset Schizophrenia.Journal of child and adolescent psychopharmacology · 2016Trial
- Paternal age, de novo mutation, and age at onset among co-affected schizophrenia sib-pairs: whole-genome sequencing in multiplex families.Molecular psychiatry · 2025Article
- The relationship between visual hallucinations, functioning, and suicidality over the course of illness: a 10-year follow-up study in first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2024Article
- Copy Number Variations in Neuropsychiatric Disorders.International journal of molecular sciences · 2023Review
- Consensus on potential biomarkers developed for use in clinical tests for schizophrenia.General psychiatry · 2022Article
- Exploration of Mutated Genes and Prediction of Potential Biomarkers for Childhood-Onset Schizophrenia Using an Integrated Bioinformatic Analysis.Frontiers in aging neuroscience · 2022Article
- A Pilot Study on Early-Onset Schizophrenia Reveals the Implication of Wnt, Cadherin and Cholecystokinin Receptor Signaling in Its Pathophysiology.Frontiers in genetics · 2021Article
- Obstacles to diagnostic investigation of a child with comorbid psychiatric conditions.Scandinavian journal of child and adolescent psychiatry and psychology · 2021Article
- Sleep spindle activity in childhood onset schizophrenia: Diminished and associated with clinical symptoms.Schizophrenia research · 2020Article
- Progress in iPSC-Based Modeling of Psychiatric Disorders.International journal of molecular sciences · 2019Review
- Social skills, executive functioning and social engagement.Schizophrenia research. Cognition · 2019Article
- Children in Need-Diagnostics, Epidemiology, Treatment and Outcome of Early Onset Anorexia Nervosa.Nutrients · 2019Review
- Childhood-Onset Schizophrenia: Insights from Induced Pluripotent Stem Cells.International journal of molecular sciences · 2018Review
- Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- A novel de novo mutation in ATP1A3 and childhood-onset schizophrenia.Cold Spring Harbor molecular case studies · 2016Article
- 15q13.3 duplication in two patients with childhood-onset schizophrenia.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Stratification by age at onset has been useful for genetic studies across all of medicine. For the past 20 years, the National Institute of Mental Health has been systematically recruiting patients with onset of schizophrenia before age 13 years. Examination of familial transmission of known candidate risk genes was carried out, and a 10% rate of cytogenetic abnormalities was found. Most recently, high-density, array-based scans for submicroscopic rare copy number variations (CNVs) have suggested that this kind of genetic variation occurs more frequently than expected by chance in childhood-onset schizophrenia (COS) and at a higher rate than observed in adult-onset disorder. Several CNVs and cytogenetic abnormalities associated with COS are also seen in autism and mental retardation. Populations with COS may have more salient genetic influence than adult-onset cases. The relationship of rare CNVs to prepsychotic development is being studied further.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.