Evidence map›Paper›PMID 19302409›Full record

ArticleBiometrics2009

Shrinkage-based diagonal discriminant analysis and its applications in high-dimensional data.

Herbert Pang, Tiejun Tong, Hongyu Zhao

Abstract read
In one paragraph

Article in Biometrics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
  2. Article
  3. Better-than-chance classification for signal detection.Biostatistics (Oxford, England) · 2021
    Article
  4. Sparse Linear Discriminant Analysis using the Prior-Knowledge-Guided Block Covariance Matrix.Chemometrics and intelligent laboratory systems : an international journal sponsored by the Chemometrics Society · 2020
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Block-diagonal discriminant analysis and its bias-corrected rules.Statistical applications in genetics and molecular biology · 2013
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Herbert PangDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina 27705, USA. herbert.pang@duke.edu
Tiejun Tong
Hongyu Zhao

Funding

Yale/NIDA Neuroproteomics Research CenterP30DA018343 · NIDA · YALE UNIVERSITY · PI Marina R Picciotto · 2004 to 2026
$37.1M
Yale Microarray Center for Research the Nervous SystemU24NS051869 · NINDS · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2005 to 2009
$6.9M
STATISTICAL METHODS TO MAP GENES FOR COMPLEX TRAITSR01GM059507 · NIGMS · YALE UNIVERSITY · PI ZHAO, HONGYU · 1999 to 2013
$3.6M
YALE BIOMEDICAL SUPERCOMPUTER: NEUROSCIENCES10RR019895 · NCRR · YALE UNIVERSITY · PI WILLIAMS, KENNETH ROBERT · 2004 to 2004
$1.6M
NCRR NIH HHS RR19895NCRR NIH HHS S10 RR019895NHLBI NIH HHS N01 HV28286NIDA NIH HHS P30 DA018343NIGMS NIH HHS R01 GM059507NIGMS NIH HHS R01 GM59507NINDS NIH HHS U24 NS051869
6 · The paper itself

Abstract

High-dimensional data such as microarrays have brought us new statistical challenges. For example, using a large number of genes to classify samples based on a small number of microarrays remains a difficult problem. Diagonal discriminant analysis, support vector machines, and k-nearest neighbor have been suggested as among the best methods for small sample size situations, but none was found to be superior to others. In this article, we propose an improved diagonal discriminant approach through shrinkage and regularization of the variances. The performance of our new approach along with the existing methods is studied through simulations and applications to real data. These studies show that the proposed shrinkage-based and regularization diagonal discriminant methods have lower misclassification rates than existing methods in many cases.

Indexed as

Discriminant AnalysisBiometryHumansMultiple MyelomaNeoplasmsOligonucleotide Array Sequence Analysis

Identifiers

PMID19302409
PMCPMC2794982

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.