ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2009
Genetic and environmental contributions to allergen sensitization in a Chinese twin study.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Genome-Wide Association Study Reveals a Causal Relationship Between Allergic Rhinitis and Hazelnut Allergy.Allergy · 2025Pooled it
- Update on the genetics of allergic diseases.The Journal of allergy and clinical immunology · 2025Review
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- Maternal influences on offspring food allergy.Immunological reviews · 2024Review
- The transcription factor Nrf2 links Th2-mediated experimental allergy to food preservatives.Frontiers in immunology · 2024Article
- Comparison of the Concordance of Allergic Diseases between Monozygotic and Dizygotic Twins: A Cross-Sectional Study Using KoGES HTS Data.Journal of personalized medicine · 2023Article
- Differences in Self-Reported Food Allergy and Food-Associated Anaphylaxis by Race and Ethnicity Among SAPPHIRE Cohort Participants.The journal of allergy and clinical immunology. In practice · 2023Article
- Pathogenesis of allergic diseases and implications for therapeutic interventions.Signal transduction and targeted therapy · 2023Review
- Environmental Exposures may Hold the Key; Impact of Air Pollution, Greenness, and Rural/Farm Lifestyle on Allergic Outcomes.Current allergy and asthma reports · 2023Review
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- Genetics of Food Allergy.Immunology and allergy clinics of North America · 2021Review
- The Phenotype of the Food-Allergic Patient.Immunology and allergy clinics of North America · 2021Review
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- The Vista of Application of Specific Anaphylaxis Accurate Diagnosis Based on DNA Single-Nucleotide Methylation Sites.Contrast media & molecular imaging · 2021Article
- Advancing Food Allergy Through Omics Sciences.The journal of allergy and clinical immunology. In practice · 2021Review
- Current insights into the genetics of food allergy.The Journal of allergy and clinical immunology · 2021Review
- Suspected Anaphylactic Reaction to Ketamine in 3 Yucatan Swine (Comparative medicine · 2019Article
- Mechanisms of gastrointestinal allergic disorders.The Journal of clinical investigation · 2019Review
- Influences on allergic mechanisms through gut, lung, and skin microbiome exposures.The Journal of clinical investigation · 2019Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAllergic disease is on the rise worldwide. Effective prevention of allergic disease requires comprehensive understanding of the factors that contribute to its intermediate phenotypes, such as sensitization to common allergens.
objectiveTo estimate the degree of genetic and environmental contributions to sensitization to food and aeroallergens.
methodsSensitization was defined as a positive skin prick test to an allergen. We calculated the zygosity-specific concordance rates and odds ratios (ORs) for sensitization to food and aeroallergens in 826 Chinese twin pairs [472 monozygotic (MZ) and 354 dizygotic (DZ)] aged 12-28 years. We also applied structural equation modelling procedures to estimate genetic and environmental influences on sensitization.
resultsThe concordance rates and risk of sensitization in one twin given the presence vs. the absence of sensitization in the other twin were higher in MZ twins than those in DZ twins. However, a large number of MZ twins were discordant in sensitization to common allergens. These observations suggest both genetic and environmental factors influence sensitization. Consistently, the estimated heritability and individual environmental components of the liability to sensitization ranged from 0.51 to 0.68 and 0.32 to 0.49, respectively, based on the best-fitted structural equation model. We also observed high phenotypic correlations between sensitization to two aeroallergens (cockroach and dust mite: 0.83) and two food allergens (peanut and shellfish: 0.58), but only moderate correlations for the pairs between sensitization to a food and an aeroallergen (0.31-0.46). The shared genetic and environmental factors between paired sensitizations contribute to the observed correlations.
conclusionWe demonstrated that sensitization to common food and aeroallergens were influenced by both genetic and environmental factors. Moreover, we found that paired allergen sensitizations might share some common sets of genes and environmental factors. This study underscores the need to further delineate unique and/or pleiotropic genetic and environmental factors for allergen sensitization.
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