ArticleBreastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine2009
Breastmilk from allergic mothers can protect offspring from allergic airway inflammation.
Article in Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Maternal asthma imprints fetal lung ILC2s via glucocorticoid signaling leading to worsened allergic airway inflammation in murine adult offspring.Nature communications · 2025Article
- The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?International journal of environmental research and public health · 2021Review
- Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy.Frontiers in immunology · 2019Review
- Low Mother-to-Child CCL22 Chemokine Levels Are Inversely Related to Mite Sensitization and Asthma in Early Childhood.Scientific reports · 2018Article
- Maternal IgG immune complexes induce food allergen-specific tolerance in offspring.The Journal of experimental medicine · 2018Article
- Breastfeeding associated with higher lung function in African American youths with asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2017Article
- A prospective birth cohort study of different risk factors for development of allergic diseases in offspring of non-atopic parents.Oncotarget · 2017Article
- Breast Milk and Solid Food Shaping Intestinal Immunity.Frontiers in immunology · 2015Review
- FcRn-mediated intestinal absorption of IgG anti-IgE/IgE immune complexes in mice.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2012Article
- Genetic susceptibility to hypertensive renal disease.Cellular and molecular life sciences : CMLS · 2012Review
- Mendelian and trans-generational inheritance in hypertensive renal disease.Annals of medicine · 2012Review
- Participation in the Supplemental Nutrition Program for Women, Infants and Children (WIC) and breastfeeding: national, regional, and state level analyses.Maternal and child health journal · 2012Article
- Community based participatory research of breastfeeding disparities in African American women.Infant, child & adolescent nutrition · 2011Article
- IgG transmitted from allergic mothers decreases allergic sensitization in breastfed offspring.Clinical and molecular allergy : CMA · 2010Article
- Food allergy: separating the science from the mythology.Nature reviews. Gastroenterology & hepatology · 2010Review
- Maternal allergen immunisation to prevent sensitisation in offspring: Th2-polarising adjuvants are more efficient than a Th1-polarising adjuvant in mice.BMC immunology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveBreastfeeding is associated with a reduced risk of developing asthma in children. Using a murine model we previously demonstrated that mothers with Th1-type immunity to ovalbumin (OVA) transfer antigen-specific protection from OVA-induced allergic airway disease (AAD) to their offspring. The aim of this study was to evaluate the contribution of breastmilk and maternal B cell immunity from allergic mothers in the vertical transmission of protection from AAD.
methodsThis was investigated using an adoptive nursing strategy. Naive offspring were nursed by allergic wild-type or B cell-deficient foster mothers with histories of Th2-type immunity to OVA. Following weaning, offspring were immunized with OVA-Al(OH)(3) and challenged with aerosolized OVA to induce AAD.
resultsOffspring nursed by wild-type OVA-immune foster mothers demonstrated lower levels of OVA-specific immunoglobulin E, interleukin-5, and airway eosinophilia than progeny nursed by naive control mothers. In contrast, offspring nursed by B cell-deficient OVA-immune foster mothers had similar parameters of OVA-induced AAD as progeny nursed by naive control mothers.
conclusionsThese data demonstrate the ability of breastmilk from allergic mothers to protect offspring from AAD was dependent on intact maternal B cell immunity. Nursing alone, when done by wild-type mothers with AAD, was sufficient for offspring to acquire the antigen-specific protective factor(s) from breastmilk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.