ArticleThe journal of physical chemistry. B2009
Efficient escape from endosomes determines the superior efficiency of multicomponent lipoplexes.
Article in The journal of physical chemistry. B, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Non-Invasive Delivery of CRISPR/Cas9 Ribonucleoproteins (Cas9 RNPs) into Cells via Nanoparticles for Membrane Transport.Pharmaceutics · 2025Review
- Microfluidic Formulation of DNA-Loaded Multicomponent Lipid Nanoparticles for Gene Delivery.Pharmaceutics · 2021Article
- Inhibiting the Growth of 3D Brain Cancer Models with Bio-Coronated Liposomal Temozolomide.Pharmaceutics · 2021Article
- Quantitative evaluation of DNA dissociation from liposome carriers and DNA escape from endosomes during lipid-mediated gene delivery.Human gene therapy methods · 2014Article
- Exploiting endocytosis for nanomedicines.Cold Spring Harbor perspectives in biology · 2013Review
- The role of cytoskeleton networks on lipid-mediated delivery of DNA.Therapeutic delivery · 2013Article
- Quantitative measurement of intracellular transport of nanocarriers by spatio-temporal image correlation spectroscopy.Methods and applications in fluorescence · 2013Article
- Engineered nanomaterial uptake and tissue distribution: from cell to organism.International journal of nanomedicine · 2013Review
- Cationic liposome/DNA complexes: from structure to interactions with cellular membranes.European biophysics journal : EBJ · 2012Review
- Article
- The statistics of protein expression ratios for cellular fluorescence studies.European biophysics journal : EBJ · 2012Article
- Role of temperature-independent lipoplex-cell membrane interactions in the efficiency boost of multicomponent lipoplexes.Cancer gene therapy · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Designer multicomponent lipoplexes have recently emerged as especially promising transfection candidates, since they are from 10 to 100 times more efficient than binary complexes usually employed for gene delivery purposes. Here, we show, for the first time, that after internalization binary complexes of lower transfection potency remain in compact perinuclear endosomes, while multicomponent systems have intrinsic endosomal rupture properties that allow plasmid DNA to escape from endosomes with extremely high efficiency. Endosomal rupture results in an extraordinarily homogeneous distribution of unbound plasmid DNA throughout the cytoplasm and in the nucleus.
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Registered trials
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