ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Kit and foxd3 genetically interact to regulate melanophore survival in zebrafish.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Embryonic stem cell factor FOXD3 (Genesis) defects in gastrointestinal stromal tumors.Endocrine-related cancer · 2023Article
- Zebrafish Syndromic Albinism Models as Tools for Understanding and Treating Pigment Cell Disease in Humans.Cancers · 2022Review
- Functional coordination of non-myocytes plays a key role in adult zebrafish heart regeneration.EMBO reports · 2021Article
- Article
- Protein Kinase A Signaling Inhibits Iridophore Differentiation in Zebrafish.Journal of developmental biology · 2018Article
- Involvement of Delta/Notch signaling in zebrafish adult pigment stripe patterning.Development (Cambridge, England) · 2014Article
- A dynamic code of dorsal neural tube genes regulates the segregation between neurogenic and melanogenic neural crest cells.Development (Cambridge, England) · 2013Article
- Maintenance of melanophore morphology and survival is cathepsin and vps11 dependent in zebrafish.PloS one · 2013Article
- Foxd3 is an essential Nodal-dependent regulator of zebrafish dorsal mesoderm development.Developmental biology · 2010Article
- Foxd3 controls melanophore specification in the zebrafish neural crest by regulation of Mitf.Developmental biology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We have investigated the role of foxd3 activity in conjunction with signaling by the kit tyrosine kinase receptor in zebrafish black pigment cell (melanophore) development. As loss-of-function of these molecules individually has distinct effects on melanophore number, we have examined the phenotype of double mutants. Individuals with a null mutation in kit have fewer melanophores than wild-type, with cells lost through death. When kit mutants are injected with foxd3 antisense morpholino oligonucleotides or crossed with a foxd3 zebrafish mutant, they have more melanophores than their uninjected or foxd3+ counterparts. Examination of foxd3 loss-of-function in two additional kit mutants that differentially alter kit-dependent migration and survival indicates a change in melanophore number in survival mutants only. Consistently, TUNEL (terminal deoxynucleotidyl transferase-mediated deoxyuridinetriphosphate nick end-labeling) analysis confirms a partial rescue of melanophores from cell death. Ectopic expression of foxd3 indicates that foxd3 promotes early melanophore death only when kit is inactive. Taken together, these data suggest a kit-dependent role for foxd3 in the regulation of melanophore survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.