ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Transcriptional control of Rohon-Beard sensory neuron development at the neural plate border.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Rohon-beard neurons do not succumb to programmed cell death during zebrafish development.Developmental biology · 2024Article
- Single-Cell Analysis of Rohon-Beard Neurons Implicates Fgf Signaling in Axon Maintenance and Cell Survival.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Human split hand/foot variants are not as functional as wildtype human PRDM1 in the rescue of craniofacial defects.Birth defects research · 2024Article
- PRDM1 DNA-binding zinc finger domain is required for normal limb development and is disrupted in split hand/foot malformation.Disease models & mechanisms · 2023Article
- Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-mediated kif15 mutations accelerate axonal outgrowth during neuronal development and regeneration in zebrafish.Traffic (Copenhagen, Denmark) · 2019Article
- Requirement of zebrafish pcdh10a and pcdh10b in melanocyte precursor migration.Developmental biology · 2018Article
- Zebrafish In Situ Spinal Cord Preparation for Electrophysiological Recordings from Spinal Sensory and Motor Neurons.Journal of visualized experiments : JoVE · 2017Article
- Genetic pathways for differentiation of the peripheral nervous system in ascidians.Nature communications · 2015Article
- Transcriptional regulator PRDM12 is essential for human pain perception.Nature genetics · 2015Article
- Spinal neurons require Islet1 for subtype-specific differentiation of electrical excitability.Neural development · 2014Article
- Six1 is a key regulator of the developmental and evolutionary architecture of sensory neurons in craniates.BMC biology · 2014Article
- piezo2b regulates vertebrate light touch response.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Regulation of neurogenesis by Fgf8a requires Cdc42 signaling and a novel Cdc42 effector protein.Developmental biology · 2013Article
- Prdm1a directly activates foxd3 and tfap2a during zebrafish neural crest specification.Development (Cambridge, England) · 2013Article
- The evolutionary and genetic origins of consciousness in the Cambrian Period over 500 million years ago.Frontiers in psychology · 2013Article
- Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.Developmental biology · 2012Article
- Genetic susceptibility to inflammation and colonic transit in lower functional gastrointestinal disorders: preliminary analysis.Neurogastroenterology and motility · 2011Article
- prdm1a and olig4 act downstream of Notch signaling to regulate cell fate at the neural plate border.Developmental biology · 2011Article
- Identification and modulation of voltage-gated Ca2+ currents in zebrafish Rohon-Beard neurons.Journal of neurophysiology · 2011Article
- prdm1a Regulates sox10 and islet1 in the development of neural crest and Rohon-Beard sensory neurons.Genesis (New York, N.Y. : 2000) · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Rohon-Beard (RB) mechanosensory neurons are among the first sensory neurons to develop, and the process by which they adopt their fate is not completely understood. RBs form at the neural plate border (NPB), the junction between neural and epidermal ectoderm, and require the transcription factor prdm1a. Here, we show that prior to RB differentiation, prdm1a overlaps extensively with the epidermal marker dlx3b but shows little overlap with the neuroectodermal markers sox3 and sox19a. Birthdating analysis reveals that the majority of RBs are born during gastrulation in zebrafish, suggesting that it is during this period that RBs become specified. Expression analysis in prdm1a and neurogenin1 mutant and dlx3b/dlx4b morpholino-injected embryos suggests that prdm1a is upstream of dlx3b, dlx4b, and neurogenin1 at the NPB. mRNA for neurogenin1 or dlx3b/dlx4b can rescue the lack of RBs in prdm1a mutants. Based on these data, we suggest a preliminary gene regulatory network for RB development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.