Evidence map›Paper›PMID 19301312›Full record

ArticleChembiochem : a European journal of chemical biology2009

The puzzle of RNAs that target gene promoters.

Scott T Younger, David R Corey

Open access · greenAbstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Human RNAi pathway: crosstalk with organelles and cells.Functional & integrative genomics · 2014
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Scott T YoungerDepartment of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390-9041, USA.
David R Corey
Southwestern Medical Center

Funding

MECHANISMS OF DRUG ACTION AND DISPOSITIONT32GM007062 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI MANGELSDORF, DAVID J · 1985 to 2020
$7.4M
Recognition of Chromosomal DNA by Double-Stranded RNAR01GM077253 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI COREY, DAVID R · 2007 to 2010
$1.5M
NIGMS NIH HHS GM07062NIGMS NIH HHS R01 GM077253NIGMS NIH HHS T32 GM007062PHS HHS 77253
6 · The paper itself

Abstract

Setting the right target: Most researchers who use small RNAs in mammalian cells assume that mRNA will be the target. Recent studies suggest that small RNAs can also target chromosomal DNA. Few discoveries have had the impact of RNAi. Most researchers who use small RNAs to control gene expression in mammalian cells assume that mRNA will be the target. Recent studies, however, have suggested that small RNAs can also target chromosomal DNA.

Indexed as

Gene Expression RegulationPromoter Regions, GeneticEukaryotic Initiation Factor-2RNA, AntisenseRNA, Double-StrandedRNA, MessengerRNA, UntranslatedEukaryotic Initiation Factor-2RNA, AntisenseRNA, Double-StrandedRNA, MessengerRNA, Untranslated

Identifiers

PMID19301312
PMCPMC2759896
OpenAlexW2131718572

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.