ArticleMedical & biological engineering & computing2009
Mathematical modeling of electrical activity of uterine muscle cells.
Article in Medical & biological engineering & computing, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- A multiscale PBPK-PD model of oxytocin-induced uterine excitation and contraction.The Journal of physiology · 2026Article
- The Pathophysiology of Spontaneous Preterm Birth: Emerging Mechanisms Reviewed by the Preterm Birth International Collaborative.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- An update on pacemaking in the myometrium.The Journal of physiology · 2026Review
- In Silico Electrophysiological Investigation of Transient Receptor Potential Melastatin-4 Ion Channel Biophysics to Study Detrusor Overactivity.International journal of molecular sciences · 2024Article
- Biophysical Mechanisms of Vaginal Smooth Muscle Contraction: The Role of the Membrane Potential and Ion Channels.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Review
- Oxytocin augmentation and neurotransmitters in prolonged delivery: An experimental appraisal.European journal of obstetrics & gynecology and reproductive biology: X · 2024Article
- Steady-state approximations for Hodgkin-Huxley cell models: Reduction of order for uterine smooth muscle cell model.PLoS computational biology · 2023Article
- A complete biomechanical model ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Pattern Formation in a Spatially Extended Model of Pacemaker Dynamics in Smooth Muscle Cells.Bulletin of mathematical biology · 2022Article
- Modeling and experimental approaches for elucidating multi-scale uterine smooth muscle electro- and mechano-physiology: A review.Frontiers in physiology · 2022Review
- A computational model of excitation and contraction in uterine myocytes from the pregnant rat.Scientific reports · 2018Article
- A biophysically constrained computational model of the action potential of mouse urinary bladder smooth muscle.PloS one · 2018Article
- Reconstruction of Cell Surface Densities of Ion Pumps, Exchangers, and Channels from mRNA Expression, Conductance Kinetics, Whole-Cell Calcium, and Current-Clamp Voltage Recordings, with an Application to Human Uterine Smooth Muscle Cells.PLoS computational biology · 2016Article
- Modeling Magnetomyograms of Uterine Contractions during Pregnancy Using a Multiscale Forward Electromagnetic Approach.PloS one · 2016Article
- The role of cellular coupling in the spontaneous generation of electrical activity in uterine tissue.PloS one · 2015Article
- Spatial heterogeneity enhances and modulates excitability in a mathematical model of the myometrium.Journal of the Royal Society, Interface · 2013Article
- Multiscale forward electromagnetic model of uterine contractions during pregnancy.BMC medical physics · 2012Article
- Article
- On the prediction of premature births in Hispanic labour patients using uterine contractions, heart beat signals and prediction machines.Healthcare technology lettersArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The uterine electrical activity is an efficient parameter to study the uterine contractility. In order to understand the ionic mechanisms responsible for its generation, we aimed at building a mathematical model of the uterine cell electrical activity based upon the physiological mechanisms. First, based on the voltage clamp experiments found in the literature, we focus on the principal ionic channels and their cognate currents involved in the generation of this electrical activity. Second, we provide the methodology of formulations of uterine ionic currents derived from a wide range of electrophysiological data. The model is validated step by step by comparing simulated voltage-clamp results with the experimental ones. The model reproduces successfully the generation of single spikes or trains of action potentials that fit with the experimental data. It allows analyzing ionic channels implications. Likewise, the calcium-dependent conductance influences significantly the cellular oscillatory behavior.
Indexed as
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19301052What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.