ReviewPediatric surgery international2009
Current concepts regarding the pathogenesis of necrotizing enterocolitis.
Review in Pediatric surgery international, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Oral immunoglobulin for preventing necrotizing enterocolitis in preterm and low birth weight neonates.The Cochrane database of systematic reviews · 2016Pooled it
- Arginine supplementation in prevention of necrotizing enterocolitis in the premature infant: an updated systematic review.BMC pediatrics · 2014Pooled it
- Are Immune Modulating Single Nucleotide Polymorphisms Associated with Necrotizing Enterocolitis?Scientific reports · 2015Trial
- Visceral Pain in Preterm Infants with Necrotizing Enterocolitis: Underlying Mechanisms and Implications for Treatment.Paediatric drugs · 2025Review
- Novel pathogenic GATA6 variant associated with congenital heart disease, diabetes mellitus and necrotizing enterocolitis.Pediatric research · 2024Article
- Fetal Doppler Evaluation to Predict NEC Development.Journal of personalized medicine · 2022Article
- Interpretable prediction of necrotizing enterocolitis from machine learning analysis of premature infant stool microbiota.BMC bioinformatics · 2022Article
- miRNA-21 plays an important role in necrotizing enterocolitis.Archives of medical science : AMS · 2022Article
- Stress and corticotropin releasing factor (CRF) promote necrotizing enterocolitis in a formula-fed neonatal rat model.PloS one · 2021Article
- Platelet transfusions and mortality in necrotizing enterocolitis.Transfusion · 2019Article
- Hyaluronan 35kDa treatment protects mice from Citrobacter rodentium infection and induces epithelial tight junction protein ZO-1 in vivo.Matrix biology : journal of the International Society for Matrix Biology · 2017Article
- Changes in plasma and urinary nitrite after birth in premature infants at risk for necrotizing enterocolitis.Pediatric research · 2016Article
- Roles of nitric oxide and intestinal microbiota in the pathogenesis of necrotizing enterocolitis.Journal of pediatric surgery · 2016Review
- Necrotizing enterocolitis in a mouse model leads to widespread renal inflammation, acute kidney injury, and disruption of renal tight junction proteins.Pediatric research · 2015Article
- Pathogenesis of neonatal necrotizing enterocolitis.Pediatric surgery international · 2015Review
- Role of cyclooxygenase-2 in intestinal injury in neonatal rats.Biomedical reports · 2014Article
- Late onset of necrotizing enterocolitis in the full-term infant is associated with increased mortality: results from a two-center analysis.Journal of pediatric surgery · 2014Article
- Changes in intestinal glucocorticoid sensitivity in early life shape the risk of epithelial barrier defect in maternal-deprived rats.PloS one · 2014Article
- Low doses of celecoxib attenuate gut barrier failure during experimental peritonitis.Laboratory investigation; a journal of technical methods and pathology · 2013Article
- The effect of acute hypoxia on short-circuit current and epithelial resistivity in biopsies from human colon.Digestive diseases and sciences · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Necrotizing enterocolitis (NEC) is a devastating disease that predominantly affects premature neonates. The mortality associated with NEC has not changed appreciably over the past several decades. The underlying etiology of NEC remains elusive, although bacterial colonization of the gut, formula feeding, and perinatal stress have been implicated as putative risk factors. The disease is characterized by massive epithelial destruction, which results in gut barrier failure. The exact molecular and cellular mechanisms involved in this complex disease are poorly understood. Recent studies have provided significant insight into our understanding of the pathogenesis of NEC. Endogenous mediators such as prostanoids, cyclooxygenases, and nitric oxide may play a role in the development of gut barrier failure. Understanding the structural architecture of the gut barrier and the cellular mechanisms that are responsible for gut epithelial damage could lead to the development of novel diagnostic, prophylactic and therapeutic strategies in NEC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.