ReviewJournal of neurology2008
Animal models of multiple sclerosis for the development and validation of novel therapies - potential and limitations.
Review in Journal of neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Monoclonal Antibodies in Preclinical EAE Models of Multiple Sclerosis: A Systematic Review.International journal of molecular sciences · 2017Pooled it
- Astaxanthin Reduces Demyelination and Oligodendrocytes Death in A Rat Model of Multiple Sclerosis.Cell journal · 2021Article
- The Effects of Intestinal Nematode L4 Stage on Mouse Experimental Autoimmune Encephalomyelitis.Archivum immunologiae et therapiae experimentalis · 2018Article
- Murine Cytomegalovirus Infection Induces Susceptibility to EAE in Resistant BALB/c Mice.Frontiers in immunology · 2017Article
- The role of Sema4A in angiogenesis, immune responses, carcinogenesis, and retinal systems.Cell adhesion & migration · 2016Review
- Glutamate release machinery is altered in the frontal cortex of rats with experimental autoimmune encephalomyelitis.Molecular neurobiology · 2015Article
- Mouse Models of Primary Sjogren's Syndrome.Current pharmaceutical design · 2015Review
- Current concept in neural regeneration research: NSCs isolation, characterization and transplantation in various neurodegenerative diseases and stroke: A review.Journal of advanced research · 2014Review
- Microglia-mediated neuroinflammation is an amplifier of virus-induced neuropathology.Journal of neurovirology · 2014Review
- Swimming exercise ameliorates multiple sclerosis-induced impairment of short-term memory by suppressing apoptosis in the hippocampus of rats.Journal of exercise rehabilitation · 2014Article
- MS14 down-regulates lipocalin2 expression in spinal cord tissue in an animal model of multiple sclerosis in female C57BL/6.Iranian biomedical journal · 2014Article
- Article
- Epigallocatechin-3-gallate: a useful, effective and safe clinical approach for targeted prevention and individualised treatment of neurological diseases?The EPMA journal · 2013Article
- Elevated expression of fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) in the dorsal root ganglia and spinal cord in experimental autoimmune encephalomyelitis: implications in multiple sclerosis-induced neuropathic pain.BioMed research international · 2013Article
- Neuropathic pain in animal models of nervous system autoimmune diseases.Mediators of inflammation · 2013Article
- Clinical testing for neutralizing antibodies to interferon-β in multiple sclerosis.Therapeutic advances in neurological disorders · 2013Article
- Brain dendritic cells: biology and pathology.Acta neuropathologica · 2012Review
- Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease.American journal of physiology. Gastrointestinal and liver physiology · 2012Review
- The role of dorsal root ganglia activation and brain-derived neurotrophic factor in multiple sclerosis.Journal of cellular and molecular medicine · 2012Article
- Innate immunity in the central nervous system.The Journal of clinical investigation · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various types of experimental autoimmune encephalomyelitis (EAE) reflect some of the pathogenetic, clinical, and therapeutic features of the different forms of multiple sclerosis (MS), thereby, providing some, albeit limited, insight into the molecular and cellular basis of the human disease. Specific questions of MS therapy including the search for new therapeutic targets and strategies and their validation require investigations in different available EAE models. A survey is given of experimental therapeutic approaches that are currently under study with the most promising examples of monoclonal antibodies, gene therapy, stem cell transplantation and orally applied small molecular weight disease-modifying drugs. Reasons for therapy failure and adverse side-effects of some experimental trials are discussed. Precaution is advised, if results of new experimental approaches are translated into clinical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.