ArticleNeuropsychiatric disease and treatment2007
Dementia with Lewy bodies: Definition, diagnosis, and pathogenic relationship to Alzheimer's disease.
Article in Neuropsychiatric disease and treatment, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- The Differential Effects of Alzheimer's Disease and Lewy Body Pathology on Cognitive Performance: a Meta-analysis.Neuropsychology review · 2017Pooled it
- Motor symptoms in autopsy-confirmed Alzheimer's disease increase the risk of progression to severe cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Defining a Lewy Body: Running Up the Hill of Shifting Definitions and Evolving Concepts.Journal of Parkinson's disease · 2024Review
- New cases of dementia are rising in elderly populations in Wales, UK.Journal of the neurological sciences · 2023Article
- THE ENIGMA OF LEWY BODY DEMENTIA: A CASE REPORT.Acta clinica Croatica · 2020Article
- Treatment Options for Dementia with Lewy Bodies: A Network Meta-Analysis of Randomised Control Trials.Neurology and therapy · 2020Article
- The center of olfactory bulb-seeded α-synucleinopathy is the limbic system and the ensuing pathology is higher in male than in female mice.Brain pathology (Zurich, Switzerland) · 2019Article
- Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer's disease and dementia with Lewy bodies.Translational neurodegeneration · 2019Article
- A Review of Dementia with Lewy Bodies' Impact, Diagnostic Criteria and Treatment.Neurology and therapy · 2018Review
- Temporal-Spatial Profiling of Pedunculopontine Galanin-Cholinergic Neurons in the Lactacystin Rat Model of Parkinson's Disease.Neurotoxicity research · 2018Article
- Lewy Body Disease: Clinical and Pathological "Overlap Syndrome" Between Synucleinopathies (Parkinson Disease) and Tauopathies (Alzheimer Disease).Current neurology and neuroscience reports · 2018Review
- Metabolic Risk Factors of Alzheimer's Disease, Dementia with Lewy Bodies, and Normal Elderly: A Population-Based Study.Behavioural neurology · 2018Article
- Cingulate island sign temporally changes in dementia with Lewy bodies.Scientific reports · 2017Article
- MRI of the Swallow Tail Sign: A Useful Marker in the Diagnosis of Lewy Body Dementia?AJNR. American journal of neuroradiology · 2017Article
- Diabetes in a Large Dementia Cohort: Clinical Characteristics and Treatment From the Swedish Dementia Registry.Diabetes care · 2017Observational
- LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways.Journal of neuroinflammation · 2016Article
- Article
- The monoaminergic footprint of depression and psychosis in dementia with Lewy bodies compared to Alzheimer's disease.Alzheimer's research & therapy · 2015Article
- Mutations in RAB39B cause X-linked intellectual disability and early-onset Parkinson disease with α-synuclein pathology.American journal of human genetics · 2014Article
- New insight into neurodegeneration: the role of proteomics.Molecular neurobiology · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical dementia associated with the appearance of Lewy bodies in the cerebral cortex has been recognized for over 40 years. Until the 1990s, however, cortical Lewy body disease was thought to be a rare cause of dementia. At that time, the advent of sensitive and specific immunohistochemical techniques for highlighting these elusive structures led to the recognition of cortical Lewy body disease as a common substrate for clinical dementia. Current diagnostic criteria recognize dementia with Lewy bodies as a clinicopathological entity. Also recognized is the closely related (and perhaps biologically identical) entity of Parkinson's disease dementia, which differs from dementia with Lewy bodies only in the temporal sequence of appearance of clinical symptoms. The generic term "Lewy body disease" encompasses both entities. There is frequent and extensive overlap, both clinically and pathologically, between dementia with Lewy bodies and Alzheimer's disease. The two diseases share several genetic and environmental risk factors that have in common increased inflammatory states associated with increased disease risk. Moreover, pathological and experimental work has implicated the involvement of activated microglia and of microglia-derived interleukin-1 in the pathogenesis of the pathognomonic lesions of both diseases. Such neuroinflammatory processes may be the common link driving progression in both diseases and explaining the frequent overlap between the two diseases.
Indexed as
Identifiers
19300591PMC2656298W1597572988What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.