ArticlePLoS computational biology2009
Positional information generated by spatially distributed signaling cascades.
Article in PLoS computational biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Strong intracellular signal inactivation produces sharper and more robust signaling from cell membrane to nucleus.PLoS computational biology · 2020Article
- Article
- Spatial modeling of the membrane-cytosolic interface in protein kinase signal transduction.PLoS computational biology · 2018Article
- Spatio-temporal dynamics of a cell signal pathway with negative feedbacks: the MAPK/ERK pathway.The European physical journal. E, Soft matter · 2016Article
- Article
- Self-organizing actomyosin patterns on the cell cortex at epithelial cell-cell junctions.Biophysical journal · 2014Article
- Intracellular regulation of cell signaling cascades: how location makes a difference.Journal of mathematical biology · 2014Article
- Covalent modification cycles through the spatial prism.Biophysical journal · 2013Article
- Complexity of receptor tyrosine kinase signal processing.Cold Spring Harbor perspectives in biology · 2013Review
- Signalling by protein phosphatases and drug development: a systems-centred view.The FEBS journal · 2013Review
- Geometry sensing by self-organized protein patterns.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Signal propagation of the MAPK cascade in Xenopus oocytes: role of bistability and ultrasensitivity for a mixed problem.Journal of mathematical biology · 2012Article
- Diffusive coupling can discriminate between similar reaction mechanisms in an allosteric enzyme system.BMC systems biology · 2010Article
- Formation of intracellular concentration landscapes by multisite protein modification.Biophysical journal · 2010Article
- Signalling ballet in space and time.Nature reviews. Molecular cell biology · 2010Review
- Spatially distributed cell signalling.FEBS letters · 2009Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The temporal and stationary behavior of protein modification cascades has been extensively studied, yet little is known about the spatial aspects of signal propagation. We have previously shown that the spatial separation of opposing enzymes, such as a kinase and a phosphatase, creates signaling activity gradients. Here we show under what conditions signals stall in the space or robustly propagate through spatially distributed signaling cascades. Robust signal propagation results in activity gradients with long plateaus, which abruptly decay at successive spatial locations. We derive an approximate analytical solution that relates the maximal amplitude and propagation length of each activation profile with the cascade level, protein diffusivity, and the ratio of the opposing enzyme activities. The control of the spatial signal propagation appears to be very different from the control of transient temporal responses for spatially homogenous cascades. For spatially distributed cascades where activating and deactivating enzymes operate far from saturation, the ratio of the opposing enzyme activities is shown to be a key parameter controlling signal propagation. The signaling gradients characteristic for robust signal propagation exemplify a pattern formation mechanism that generates precise spatial guidance for multiple cellular processes and conveys information about the cell size to the nucleus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.