ArticleCell death and differentiation2009
The alpha/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins.
Article in Cell death and differentiation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- p63 in skin homeostasis and disease: molecular mechanisms and therapeutic potentials.Cell death discovery · 2026Review
- Differential Transcriptional Activity of ΔNp63β Is Encoded by an Isoform-Specific C-Terminus.Molecular and cellular biology · 2025Article
- ΔNp63 Regulates Homeostasis, Stemness, and Suppression of Inflammation in the Adult Epidermis.The Journal of investigative dermatology · 2024Article
- The role of p63 in embryonic external genitalia outgrowth in mice.Development, growth & differentiation · 2023Article
- The Splicing Factor PTBP1 RepressesCancer research communications · 2022Article
- Single-cell RNA-seq identifies a reversible mesodermal activation in abnormally specified epithelia of p63 EEC syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Late cornified envelope 1C (LCE1C), a transcriptional target of TAp63 phosphorylated at T46/T281, interacts with PRMT5.Scientific reports · 2018Article
- DNA replication timing alterations identify common markers between distinct progeroid diseases.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- TAp63γ and ΔNp63β promote osteoblastic differentiation of human mesenchymal stem cells: regulation by vitamin D3 Metabolites.PloS one · 2015Article
- A mutation in TP63 causing a mild ectodermal dysplasia phenotype.The Journal of investigative dermatology · 2014Article
- p63 is a prosurvival factor in the adult mammary gland during post-lactational involution, affecting PI-MECs and ErbB2 tumorigenesis.Cell death and differentiation · 2014Article
- ΔNp63 regulates select routes of reprogramming via multiple mechanisms.Cell death and differentiation · 2013Article
- Delineating Molecular Mechanisms of Squamous Tissue Homeostasis and Neoplasia: Focus on p63.Journal of skin cancer · 2013Article
- MicroRNA-203 contributes to skin re-epithelialization.Cell death & disease · 2012Article
- ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation.Development (Cambridge, England) · 2012Article
- p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53.Cell death and differentiation · 2011Review
- ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis.Cell death and differentiation · 2011Article
- While p73 is essential, p63 is completely dispensable for the development of the central nervous system.Cell cycle (Georgetown, Tex.) · 2011Article
- p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis.Cell death and differentiation · 2010Article
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6 authors at 2 institutions in 2 countries.
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Abstract
p63, an ancestral transcription factor of the p53 family, has three C-terminal isoforms whose relative in vivo functions are elusive. The p63 gene is essential for skin and limb development, as vividly shown by two independent global knockout mouse models. Both strains, although constructed differently, have identical and severe phenotypes, characterized by absent epidermis and hindlimbs and only rudimentary forelimbs at birth. Here we show that mice from one model, Brdm2, express normal levels of truncated p63 proteins that contain the DNA binding and oligomerization domain but lack the long carboxy-terminal SAM (sterile alpha-motif) and post-SAM domains that are specific for the alpha and beta isoforms. As such, transcriptionally active p63 proteins from Brdm2 mice resemble the naturally occurring p63gamma isoforms, which of all the p63 isoforms most closely resemble p53. Thus, Brdm2 mice are p63alpha/beta isoform-specific knockout mice, gaining unexpected new importance. Our studies identify that p63alpha/beta but not p63gamma are absolutely required for proper skin and limb development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.