ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2009
Cholinergic giant migrating contractions in conscious mouse colon assessed by using a novel noninvasive solid-state manometry method: modulation by stressors.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Pooled it
- Influence of Sacral and Thoracolumbar Spinal Nerve Electrical Stimulation on Colonic Motility in Anesthetized Yucatan Male Pigs.Neurogastroenterology and motility · 2026Article
- Article
- In vivo imaging of vagal-induced myenteric plexus responses in gastrointestinal tract with an optical window.Nature communications · 2024Article
- Involvement of acid sensing ion channel (ASIC)-3 in an acute urinary bladder-colon cross sensitization model in rodent.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Bio-impedance method to monitor colon motility response to direct distal colon stimulation in anesthetized pigs.Scientific reports · 2022Article
- The effect of colonic tissue electrical stimulation and celiac branch of the abdominal vagus nerve neuromodulation on colonic motility in anesthetized pigs.Neurogastroenterology and motility · 2020Article
- First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques.Nature reviews. Gastroenterology & hepatology · 2019Review
- Anatomical and Functional Changes to the Colonic Neuromuscular Compartment after Experimental Spinal Cord Injury.Journal of neurotrauma · 2018Article
- VIP is involved in peripheral CRF-induced stimulation of propulsive colonic motor function and diarrhea in male rats.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Brain and Gut CRF Signaling: Biological Actions and Role in the Gastrointestinal Tract.Current molecular pharmacology · 2018Review
- Measurement of Gastrointestinal and Colonic Motor Functions in Humans and Animals.Cellular and molecular gastroenterology and hepatology · 2016Article
- Role of Corticotropin-releasing Factor Signaling in Stress-related Alterations of Colonic Motility and Hyperalgesia.Journal of neurogastroenterology and motility · 2015Article
- Role of innate immunity and altered intestinal motility in LPS- and MnCl2-induced intestinal intussusception in mice.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Complex interactions among diet, gastrointestinal transit, and gut microbiota in humanized mice.Gastroenterology · 2013Article
- The Nav1.9 channel regulates colonic motility in mice.Frontiers in neuroscience · 2013Article
- Mice overexpressing wild-type human alpha-synuclein display alterations in colonic myenteric ganglia and defecation.Neurogastroenterology and motility · 2012Article
- Impaired propulsive motility in the distal but not proximal colon of BK channel β1-subunit knockout mice.Neurogastroenterology and motility · 2012Article
- Psychological Stress Induces Visceral Analgesic or Hyperalgesic Response in Rodents: A Role of Preconditions.Frontiers of gastrointestinal research · 2012Article
- Central somatostatin receptor 1 activation reverses acute stress-related alterations of gastric and colonic motor function in mice.Neurogastroenterology and motility · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
There is a glaring lack of knowledge on mouse colonic motility in vivo, primarily due to unavailability of adequate recording methods. Using a noninvasive miniature catheter pressure transducer inserted into the distal colon, we assessed changes in colonic motility in conscious mice induced by various acute or chronic stressors and determined the neurotransmitters mediating these changes. Mice exposed to restraint stress (RS) for 60 min displayed distal colonic phasic contractions including high-amplitude giant migrating contractions (GMCs), which had peak amplitudes >25 mmHg and occurred at a rate of 15-25 h(-1) of which over 50% were aborally propagative. Responses during the first 20-min of RS were characterized by high-frequency and high-amplitude contractions that were correlated with defecation. RS-induced GMCs and fecal pellet output were blocked by atropine (0.5 mg/kg ip) or the corticotrophin releasing factor (CRF) receptor antagonist astressin-B (100 microg/kg ip). RS activated colonic myenteric neurons as shown by Fos immunoreactivity. In mice previously exposed to repeated RS (60 min/day, 14 days), or in transgenic mice that overexpress CRF, the duration of stimulation of phasic colonic contractions was significantly shorter (10 vs. 20 min). In contrast to RS, abdominal surgery abolished colonic contractions including GMCs. These findings provide the first evidence for the presence of frequent cholinergic-dependent GMCs in the distal colon of conscious mice and their modulation by acute and chronic stressors. Noninvasive colonic manometry opens new venues to investigate colonic motor function in genetically modified mice relevant to diseases that involve colonic motility alterations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.