ArticleMolecular biology and evolution2009
Lowly expressed human microRNA genes evolve rapidly.
Article in Molecular biology and evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Transcription of microRNAs is regulated by developmental signaling pathways and transcription factors.Frontiers in cell and developmental biology · 2024Article
- Genetic characterization of Macaca arctoides: A highlight of key genes and pathways.Primates; journal of primatology · 2023Article
- MicroRNA therapeutic targets in neonatal hypoxic-ischemic brain injury: a narrative review.Pediatric research · 2023Review
- Evolution and Phylogeny of MicroRNAs - Protocols, Pitfalls, and Problems.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Variability in porcine microRNA genes and its association with mRNA expression and lipid phenotypes.Genetics, selection, evolution : GSE · 2021Article
- Small RNAs in parasitic nematodes - forms and functions.Parasitology · 2020Review
- MicroRNA-23a/27a/24-2 cluster promotes gastric cancer cell proliferation synergistically.Oncology letters · 2018Article
- MicroRNA duplication accelerates the recruitment of new targets during vertebrate evolution.RNA (New York, N.Y.) · 2018Article
- Human microRNAs preferentially target genes with intermediate levels of expression and its formation by mammalian evolution.PloS one · 2018Article
- Low genetic diversity and functional constraint of miRNA genes participating pollen-pistil interaction in rice.Plant molecular biology · 2017Article
- Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers.Genome research · 2017Article
- MicroRNA categorization using sequence motifs and k-mers.BMC bioinformatics · 2017Article
- The microRNA toolkit of insects.Scientific reports · 2016Article
- microRNAs in the Same Clusters Evolve to Coordinately Regulate Functionally Related Genes.Molecular biology and evolution · 2016Article
- Function and regulation of microRNA-31 in development and disease.Molecular reproduction and development · 2016Review
- Comparative genomic analysis of upstream miRNA regulatory motifs in Caenorhabditis.RNA (New York, N.Y.) · 2016Article
- Association genetics in Populus reveals the interactions between Pto-miR160a and its target Pto-ARF16.Molecular genetics and genomics : MGG · 2016Article
- MicroRNA evolution, expression, and function during short germband development in Tribolium castaneum.Genome research · 2016Article
- Article
- Evidence for the expression of abundant microRNAs in the locust genome.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
To study the evolution of human microRNAs (miRNAs), we examined nucleotide variation in humans, sequence divergence between species, and genomic clustering patterns for miRNAs with different expression levels. We found that expression level is a major indicator of the rate of evolution and that approximately 30% of currently annotated human miRNA genes are almost free of selective pressure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.