ArticleMolecular endocrinology (Baltimore, Md.)2009
The DREAM protein is associated with thyroid enlargement and nodular development.
Article in Molecular endocrinology (Baltimore, Md.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Calcium Signaling in the Thyroid: Friend and Foe.Cancers · 2021Article
- Inhibition of the Neuronal Calcium Sensor DREAM Modulates Presenilin-2 Endoproteolysis.Frontiers in molecular neuroscience · 2018Article
- CaFrontiers in molecular neuroscience · 2018Review
- Upregulation of TSHR, TTF-1, and PAX8 in Nodular Goiter Is Associated with Iodine Deficiency in the Follicular Lumen.International journal of endocrinology · 2016Article
- Evaluation of Downstream Regulatory Element Antagonistic Modulator Gene in Human Multinodular Goiter.Medical science monitor basic research · 2015Article
- DuOx2 Promoter Regulation by Hormones, Transcriptional Factors and the Coactivator TAZ.European thyroid journal · 2015Article
- Protein-Protein Interactions: Gene Acronym Redundancies and Current Limitations Precluding Automated Data Integration.Proteomes · 2013Article
- Ca2+-activated nucleotidase 1, a novel target gene for the transcriptional repressor DREAM (downstream regulatory element antagonist modulator), is involved in protein folding and degradation.The Journal of biological chemistry · 2012Article
- Identifying quantitative trait loci affecting resistance to congenital hypothyroidism in 129/SvJcl strain mice.PloS one · 2012Article
- Reduced Mid1 Expression and Delayed Neuromotor Development in daDREAM Transgenic Mice.Frontiers in molecular neuroscience · 2012Article
- The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Diagnostic utility of DREAM gene mRNA levels in thyroid tumours.Archives of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
G protein-coupled receptors (GPCRs) are involved in the pathophysiology of a wide range of diseases and constitute an attractive therapeutic target. In the thyroid gland, TSH receptor (TSHR), a member of the GPCR family, is a major regulator of thyroid differentiation and function. Alterations in TSHR activity are often involved in the development of pathologies such as thyroid cancer and thyroid enlargement (goiter). Here we show that DREAM (downstream regulatory element antagonist modulator) modulates TSHR activity through a direct protein-protein interaction that promotes coupling between the receptor and Galphas. In transgenic mice, DREAM overexpression provokes a marked enlargement of the thyroid gland. Increased levels of DREAM protein were observed in human multinodular goiters, suggesting a novel etiopathogenic mechanism in nodular development in humans. Taken together, these findings identify a mechanism for the control of TSHR activity and provide a new approach for the study and treatment of thyroid pathologies associated with impaired TSHR function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.