ArticleMolecular & cellular proteomics : MCP2009
Excretory/secretory proteome of the adult developmental stage of human blood fluke, Schistosoma japonicum.
Article in Molecular & cellular proteomics : MCP, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed, 182 citations in OpenAlex.
- Schistosoma japonicum cathepsin L1: A potential target for anti-schistosomiasis strategies.PLoS neglected tropical diseases · 2025Article
- Structural dynamics and binding of Caenorhabditis elegans lifespan-extending lipid binding protein-3 to polyunsaturated fatty acids.Protein science : a publication of the Protein Society · 2025Article
- Schistosoma mansoni excretory-secretory products induce protein kinase signalling, hyperkinesia, and stem cell proliferation in the opposite sex.Communications biology · 2023Article
- Identification and Characterization of Antigenic Properties ofPathogens (Basel, Switzerland) · 2022Article
- A first attempt at determining the antibody-specific pattern ofVeterinary world · 2022Article
- Differential Excretory/Secretory Proteome of the Adult Female and Male Stages of the Human Blood Fluke,Frontiers in parasitology · 2022Article
- Proteomic analysis ofFrontiers in microbiology · 2022Article
- Schistosome immunomodulators.PLoS pathogens · 2021Review
- Reduction of autofluorescence in whole adult worms of Schistosoma japonicum for immunofluorescence assay.Parasites & vectors · 2021Article
- Evidence of Immune Modulators in the Secretome of the Equine TapewormPathogens (Basel, Switzerland) · 2021Article
- Modulation of the Host Immune Response by Schistosome Egg-Secreted Proteins Is a Critical Avenue of Host-Parasite Communication.Pathogens (Basel, Switzerland) · 2021Review
- Review
- Immunoproteomic Analysis ofPathogens (Basel, Switzerland) · 2021Article
- A novel, sequencing-free strategy for the functional characterization of Taenia solium proteomic fingerprint.PLoS neglected tropical diseases · 2021Article
- CircRNA75 and CircRNA72 Function as the Sponge of MicroRNA-200 to Suppress Coelomocyte ApoptosisFrontiers in immunology · 2021Article
- Proteomics Investigations of Potential Protein Biomarkers in Sera of Rabbits Infected WithFrontiers in cellular and infection microbiology · 2021Article
- TheFrontiers in cellular and infection microbiology · 2021Article
- Identification of Myoferlin, a Potential Serodiagnostic Antigen of Clonorchiasis,Frontiers in cellular and infection microbiology · 2021Article
- A comparative proteomics analysis of the egg secretions of three major schistosome species.Molecular and biochemical parasitology · 2020Article
- Review
23 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schistosomes are the causative agents of schistosomiasis, one of the most prevalent and serious of the parasitic diseases that currently infects approximately 200 million people worldwide. Schistosome excretory/secretory (ES) proteins have been shown to play important roles in modulating mammalian host immune systems. In our current study, we performed a global proteomics identification of the ES proteins from adult worms of Schistosoma japonicum, one of the three major schistosome species. Our results unambiguously identified 101 proteins, including 53 putatively secreted proteins. By quantitative analysis, we revealed fatty acid-binding protein as a major constituent of the in vitro ES proteome. Strikingly the heat shock proteins HSP70s, HSP90, and HSP97 constituted the largest protein family in the ES proteome, implying a central role for these proteins in immunomodulation in the host-parasite relationship. Other important S. japonicum ES proteins included actins, 14-3-3, aminopeptidase, enolase, and glyceraldehyde-3-phosphate dehydrogenase, some of which have been considered as viable vaccine candidates and therapeutic targets. A comparison with previous studies suggests that 48.5% of S. japonicum ES proteins are common to other parasite ES products, indicating that the molecular mechanisms involved in evading the host immune response may be conserved across different parasites. Interestingly seven host proteins, including antimicrobial protein CAP18, immunoglobulins, and a complement component, were identified among in vitro S. japonicum ES products likely originating from the schistosome tegument or gut, indicating that host innate and acquired immune systems could defend against schistosome invasion. Our present study represents the first attempt at profiling S. japonicum ES proteins, provides an insight into host-parasite interactions, and establishes a resource for the development of diagnostic agents and vaccines for the control of schistosomiasis.
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