ReviewEndocrine reviews2009
Trophoblast stem cells: models for investigating trophectoderm differentiation and placental development.
Review in Endocrine reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 72 citations in OpenAlex.
- The dynamics of glycosylation in trophoblast cells: development, function, and pregnancy-related disorders.Annals of medicine · 2026Review
- Mouse trophectoderm stem cells generated with morula signalling inducers capture an early trophectoderm state.Nature cell biology · 2025Article
- Blastocyst-like Structures in the Peripheral Retina of Young Adult Beagles.International journal of molecular sciences · 2024Article
- Endometrial and placental stem cells in successful and pathological pregnancies.Journal of assisted reproduction and genetics · 2023Review
- Efficient derivation of human trophoblast stem cells from primed pluripotent stem cells.Science advances · 2021Article
- Establishment of macaque trophoblast stem cell lines derived from cynomolgus monkey blastocysts.Scientific reports · 2020Article
- Article
- Microphysiological systems of the placental barrier.Advanced drug delivery reviews · 2020Review
- Changes in gene expression following long-term in vitro exposure of Macaca mulatta trophoblast stem cells to biologically relevant levels of endocrine disruptors.Reproductive toxicology (Elmsford, N.Y.) · 2018Article
- Isolation and characterization of trophoblasts from enzymatic explants of human term placenta.Human cell · 2017Article
- Comparison of syncytiotrophoblast generated from human embryonic stem cells and from term placentas.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- DNA methylation dynamics at imprinted genes during bovine pre-implantation embryo development.BMC developmental biology · 2015Article
- SMAD1/5 signaling in the early equine placenta regulates trophoblast differentiation and chorionic gonadotropin secretion.Endocrinology · 2014Article
- Differentiation of trophoblast cells from human embryonic stem cells: to be or not to be?Reproduction (Cambridge, England) · 2014Article
- Trophoblast lineage cells derived from human induced pluripotent stem cells.Biochemical and biophysical research communications · 2013Article
- Comparison of extravillous trophoblast cells derived from human embryonic stem cells and from first trimester human placentas.Placenta · 2013Article
- Human placental microRNAs and preeclampsia.Biology of reproduction · 2013Review
- Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Embryonic stem cell-derived trophoblast differentiation: a comparative review of the biology, function, and signaling mechanisms.The Journal of endocrinology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The placenta is an ephemeral organ containing diverse populations of trophoblasts that are all derived from the embryonic trophectoderm but have morphological, functional, and molecular diversity within and across species. In hemochorial placentation, these cells play especially important roles, interfacing with and modifying the cells of the maternal decidua. Within the rapidly growing placenta, it has been shown that there are trophoblast stem cells well characterized in the mouse and postulated but not well understood in primates. This review will discuss the characteristics of candidates for human and nonhuman primate trophoblast stem cells, present the diverse methods of their generation, and propose future prospects for experimental systems in which they can shed light on developmental and pathophysiological processes in human pregnancy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.