ArticleClinical and experimental pharmacology & physiology2009
Role of activated intrarenal reactive oxygen species and renin-angiotensin system in IgA nephropathy model mice.
Article in Clinical and experimental pharmacology & physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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27 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Efficacy and safety of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers for IgA nephropathy in children.Pediatric nephrology (Berlin, Germany) · 2022Pooled it
- Luteolin delays the progression of IgA nephropathy by attenuating inflammation, oxidative stress and reducing extracellular matrix accumulation through activating the Nrf-2/HO-1 pathway.Frontiers in pharmacology · 2025Article
- Dietary salt with nitric oxide deficiency induces nocturnal polyuria in mice via hyperactivation of intrarenal angiotensin II-SPAK-NCC pathway.Communications biology · 2022Article
- The Urinary Angiotensinogen to Urinary Albumin Ratio Reflects Whether the Renin-angiotensin System in the Kidney Is Activated due to Filtration of Plasma Angiotensinogen through the Damaged Glomeruli or the Production of Angiotensinogen in the Proximal Tubules.Internal medicine (Tokyo, Japan) · 2020Article
- Increased heart rate is associated with intrarenal renin-angiotensin system activation in chronic kidney disease patients.Clinical and experimental nephrology · 2019Article
- The pivotal role of melatonin in ameliorating chronic kidney disease by suppression of the renin-angiotensin system in the kidney.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Review
- The Intrarenal Renin-angiotensin System Is Activated Immediately after Kidney Donation in Kidney Transplant Donors.Internal medicine (Tokyo, Japan) · 2019Article
- The Relationship between the Intrarenal Dopamine System and Intrarenal Renin-angiotensin System Depending on the Renal Function.Internal medicine (Tokyo, Japan) · 2018Article
- Melatonin ameliorates intrarenal renin-angiotensin system in a 5/6 nephrectomy rat model.Clinical and experimental nephrology · 2018Article
- Night-time activation of the intrarenal renin-angiotensin system due to nocturnal hypertension is associated with renal arteriosclerosis in normotensive IgA nephropathy patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- (Pro)renin receptor is involved in mesangial fibrosis and matrix expansion.Scientific reports · 2018Article
- Increased nocturnal blood pressure variability is associated with renal arteriolar hyalinosis in normotensive patients with IgA nephropathy.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Intrarenal renin-angiotensin system activity is augmented after initiation of dialysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Intermedin ameliorates IgA nephropathy by inhibition of oxidative stress and inflammation.Clinical and experimental medicine · 2016Article
- Plasma Soluble (Pro)renin Receptor Reflects Renal Damage.PloS one · 2016Article
- Reactive Oxygen Species and Nuclear Factor Erythroid 2-Related Factor 2 Activation in Diabetic Nephropathy: A Hidden Target.Journal of diabetes & metabolism · 2015Article
- Renoprotective effects of direct renin inhibition in glomerulonephritis.The American journal of the medical sciences · 2014Article
- Oxidative DNA damage in kidneys and heart of hypertensive mice is prevented by blocking angiotensin II and aldosterone receptors.PloS one · 2014Article
- Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC).The Journal of biological chemistry · 2013Article
- ETA activation mediates angiotensin II-induced infiltration of renal cortical T cells.Journal of the American Society of Nephrology : JASN · 2011Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
1. Using HIGA (high IgA of ddY) mice as an IgA nephropathy model and BALB/c mice as controls, we demonstrated that reactive oxygen species (ROS) and the renin-angiotensin system (RAS) were activated in kidneys of HIGA mice. However, it was difficult to establish an association between renal damage and changes in ROS and the RAS. Therefore, the present study was performed to determine whether renal injury is associated with changes in ROS and the RAS in HIGA mice. 2. Male HIGA mice were divided into four groups of 10 each: (i) untreated mice (HIGA + null); (ii) mice treated with the angiotensin AT(1) receptor antagonist olmesartan (5 mg/kg per day; HIGA + OLM); (iii) mice treated with the superoxide dismutase mimetic tempol (50 mg/kg per day; HIGA + Tempol); and (iv) mice treated with RAS-independent antihypertensive drugs (30 mg/kg per day hydralazine, 0.6 mg/kg per day reserpine and 12 mg/kg per day hydrochlorothiazide; HIGA + HRH). Mice were treated for 5 weeks. 3. Systolic blood pressure decreased significantly in the HIGA + OLM and HIGA + HRH groups, but not in the HIGA + Tempol group, compared with HIGA + null mice. The expression of two ROS markers (4-hydroxy-2-nonenal and heme oxygenase-1) and angiotensin II as a marker of the RAS decreased significantly in HIGA + OLM and HIGA + Tempol mice, but not in HIGA + HRH mice, compared with HIGA + null mice. As a marker of renal damage, mesangial matrix expansion and the desmin-positive area decreased significantly in the HIGA + OLM and HIGA + Tempol groups, but not in HIGA + HRH group, compared with the HIGA + null group. 4. These data suggest that intrarenal ROS and RAS activation play a pivotal role in the development of IgA nephropathy model mice, from the early phase, independent of blood pressure.
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