Evidence map›Paper›PMID 19298451›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2009

Treatment-dependent loss of polyfunctional CD8+ T-cell responses in HIV-infected kidney transplant recipients is associated with herpesvirus reactivation.

O Gasser, F Bihl, S Sanghavi, C Rinaldo, D Rowe, C Hess, D Stablein, M Roland, P Stock, C Brander

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00074386 (Solid Organ Transplantation in HIV), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00074386 completednot on this map

Solid Organ Transplantation in HIV: Multi-Site Study

TypeobservationalSponsorUniversity of California, San FranciscoRan2003 to 2013Enrolled275ConditionsHIV Infections, Kidney Disease, Liver Disease
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pretransplant CD4 Count Influences Immune Reconstitution and Risk of Infectious Complications in Human Immunodeficiency Virus-Infected Kidney Allograft Recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2016
    Trial
  3. Review
  4. Article
  5. Review
  6. Identification of Optimal Donor-Recipient Combinations Among Human Immunodeficiency Virus (HIV)-Positive Kidney Transplant Recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2016
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

O GasserPartners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. ogasser@partners.org
F Bihl
S Sanghavi
C Rinaldo
D Rowe
C Hess
D Stablein
M Roland
P Stock
C Brander
University of Pittsburgh · USUniversity of California, San Francisco · USEmmes (United States) · USHarvard University · USInstitució Catalana de Recerca i Estudis Avançats · ESUniversity Hospital of Basel · CHUniversity Hospital of Geneva · CH

Funding

Solid Organ Transplantation in HIV: Multi-Site StudyU01AI052748 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STOCK, PETER G · 2003 to 2010
$25.9M
NIAID NIH HHS AI052748NIAID NIH HHS U01 AI052748PHS HHS R01 067077
6 · The paper itself

Abstract

Antiretroviral-therapy has dramatically changed the course of HIV infection and HIV-infected (HIV(+)) individuals are becoming more frequently eligible for solid-organ transplantation. However, only scarce data are available on how immunosuppressive (IS) strategies relate to transplantation outcome and immune function. We determined the impact of transplantation and immune-depleting treatment on CD4+ T-cell counts, HIV-, EBV-, and Cytomegalovirus (CMV)-viral loads and virus-specific T-cell immunity in a 1-year prospective cohort of 27 HIV(+) kidney transplant recipients. While the results show an increasing breadth and magnitude of the herpesvirus-specific cytotoxic T-cell (CTL) response over-time, they also revealed a significant depletion of polyfunctional virus-specific CTL in individuals receiving thymoglobulin as a lymphocyte-depleting treatment. The disappearance of polyfunctional CTL was accompanied by virologic EBV-reactivation events, directly linking the absence of specific polyfunctional CTL to viral reactivation. The data provide first insights into the immune-reserve in HIV+ infected transplant recipients and highlight new immunological effects of thymoglobulin treatment. Long-term studies will be needed to assess the clinical risk associated with thymoglobulin treatment, in particular with regards to EBV-associated lymphoproliferative diseases.

Indexed as

AcyclovirAdultAgedAntiviral AgentsCD4 Lymphocyte CountCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell SurvivalCytomegalovirusFlow CytometryGanciclovirHerpesviridaeHerpesvirus 4, HumanHIV InfectionsHLA-A AntigensHLA-B AntigensAcyclovirAntiviral AgentsGanciclovirHLA-A AntigensHLA-B AntigensHLA-DR Antigens

Identifiers

PMID19298451
PMCPMC2746278
OpenAlexW2005571458

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.