Trial reportActa orthopaedica2009
Once-weekly oral medication with alendronate does not prevent migration of knee prostheses: A double-blind randomized RSA study.
Trial report in Acta orthopaedica, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Bisphosphonate use in patients undergoing total knee arthroplasty reduces overall and aseptic revisions and periprosthetic bone mineral density loss: A systematic review from the FP-UCBM Knee Study Group.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Pooled it
- RSA migration of total knee replacements.Acta orthopaedica · 2018Pooled it
- Effect of bisphosphonates on periprosthetic bone loss after total knee arthroplasty: a meta-analysis of randomized controlled trials.BMC musculoskeletal disorders · 2018Pooled it
- Adherence of hip and knee arthroplasty studies to RSA standardization guidelines. A systematic review.Acta orthopaedica · 2014Pooled it
- Influence of marker-selection method in radiostereometric analysis of total knee arthroplasty on tibial baseplate migration patterns: a secondary analysis of a randomized controlled trial with 5-year follow-up.Acta orthopaedica · 2024Trial
- Antiresorptive Therapy and Revision Risk After Primary Total Knee Arthroplasty: A Systematic Review and Meta-Analysis.Arthroplasty today · 2026Article
- Postoperative Bisphosphonates Use is Associated with Reduced Adverse Outcomes After Primary Total Joint Arthroplasty of Hip and Knee: A Nationwide Population-Based Cohort Study.Calcified tissue international · 2024Article
- Alendronate enhances osseointegration in a murine implant model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- No implant migration and good subjective outcome of a novel customized femoral resurfacing metal implant for focal chondral lesions.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Article
- Current methods of preventing aseptic loosening and improving osseointegration of titanium implants in cementless total hip arthroplasty: a review.The Journal of international medical research · 2018Review
- Are biologic treatments a potential approach to wear- and corrosion-related problems?Clinical orthopaedics and related research · 2014Review
- Osteoporosis and orthopedic surgery: effect of bone health on total joint arthroplasty outcome.Current rheumatology reports · 2013Review
- Zoledronic acid enhances bone-implant osseointegration more than alendronate and strontium ranelate in ovariectomized rats.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Article
- Effect of local zoledronate on implant osseointegration in a rat model.BMC musculoskeletal disorders · 2012Article
- Association between bisphosphonate use and implant survival after primary total arthroplasty of the knee or hip: population based retrospective cohort study.BMJ (Clinical research ed.) · 2011Article
- Causes of failure and etiology of painful primary total knee arthroplasty.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2011Review
- Bisphosphonates and implants: an overview.Acta orthopaedica · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeEarly migration of joint replacements is an effect of poor fixation and can predict late loosening. By reducing the bone resorption after implantation of a joint replacement, it should be possible to enhance the initial fixation of the implant. We studied the effect of once-weekly treatment with alendronate after knee replacement. PATIENTS AND
methodsWe recruited 60 patients (60 knees) with gonarthrosis who were scheduled for a total knee replacement. They were operated on with identical implants and uncemented fixation. 30 patients were treated with a bisphosphonate (alendronate) and 30 patients underwent placebo treatment. The treatment started postoperatively and continued on a weekly basis for 6 months. The fixation of the implants was measured with repeated radiostereometry for 2 years.
resultsThere was no difference in migration of implants between the two groups.
conclusionWith uncemented fixation of knee implants, no benefit of once-weekly treatment with alendronate, starting postoperatively, could be seen during a 2-year follow-up period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.