ArticleProceedings of the National Academy of Sciences of the United States of America2009
Endometrium as an early sensor of in vitro embryo manipulation technologies.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
71 citing papers in PubMed, 242 citations in OpenAlex.
- Placental development during early pregnancy in sheep: effects of embryo origin on fetal and placental growth and global methylation.Theriogenology · 2013Trial
- Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos.PloS one · 2012Trial
- Cervico-vaginal ISGs and interferon tau: emerging biomarkers for early pregnancy detection in cattle.Veterinary research communications · 2026Review
- Molecular Regulation of Post-Hatching Embryo Development: Implications for Early Pregnancy Losses in Livestock Species.Reproduction in domestic animals = Zuchthygiene · 2026Review
- Pregnancy Outcomes Following Artificial Insemination and Embryo Transfer in Dairy Cows-Expectations vs. Reality.Reproduction in domestic animals = Zuchthygiene · 2026Review
- In vitro processes alter the embryonic disc epigenome and transcriptome in the pre-implantation elongated bovine embryo†.Biology of reproduction · 2026Article
- The Fallopian tube: Biosensor and dynamic regulator of preimplantation development.PNAS nexus · 2026Review
- Bovine endometrial organoids: a new tool to study conceptus-maternal interactions in mammals†.Biology of reproduction · 2026Article
- Blastocyst-Secreted miR-519d-3p Modulated the Cell Viability, Apoptosis and Migration of Human Endometrial Stromal Cells by Targeting HIF1α.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Bovine Endometrium Drives and Responds to Divergence of In Vitro Produced Conceptus Biochemistry.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Article
- Expression of MHC I Isoforms in Bovine Placentomes: Impact of Cloning.Veterinary sciences · 2025Article
- Enhancing integration of the dairy and beef sectors through application of assisted reproductive technologies: pregnancy outcomes following timed AI and timed ET in lactating dairy cows.Animal reproduction · 2025Article
- Gene profiles of peripheral white blood cells as potential predictors of pregnancy in embryo-recipient heifers.PloS one · 2025Article
- Article
- LPS Disrupts Endometrial Receptivity by Inhibiting STAT1 Phosphorylation in Sheep.International journal of molecular sciences · 2024Article
- Multi-omics analyses and machine learning prediction of oviductal responses in the presence of gametes and embryos.bioRxiv : the preprint server for biology · 2024Article
- Altered microRNA composition in the uterine lumen fluid in cattle (Bos taurus) pregnancies initiated by artificial insemination or transfer of an in vitro produced embryo.Journal of animal science and biotechnology · 2024Article
- Oviductal extracellular vesicles miRNA cargo varies in response to embryos and their quality.BMC genomics · 2024Article
- Oviduct and endometrial epithelium improve in vitro produced bovine embryo developmental kinetics.Reproduction (Cambridge, England) · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implantation is crucial for placental development that will subsequently impact fetal growth and pregnancy success with consequences on postnatal health. We postulated that the pattern of genes expressed by the endometrium when the embryo becomes attached to the mother uterus could account for the final outcome of a pregnancy. As a model, we used the bovine species where the embryo becomes progressively and permanently attached to the endometrium from day 20 of gestation onwards. At that stage, we compared the endometrial genes profiles in the presence of an in vivo fertilized embryo (AI) with the endometrial patterns obtained in the presence of nuclear transfer (SCNT) or in vitro fertilized embryos (IVF), both displaying lower and different potentials for term development. Our data provide evidence that the endometrium can be considered as a biological sensor able to fine-tune its physiology in response to the presence of embryos whose development will become altered much later after the implantation process. Compared with AI, numerous biological functions and several canonical pathways with a major impact on metabolism and immune function were found to be significantly altered in the endometrium of SCNT pregnancies at implantation, whereas the differences were less pronounced with IVF embryos. Determining the limits of the endometrial plasticity at the onset of implantation should bring new insights on the contribution of the maternal environment to the development of an embryo and the success of pregnancy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.