ArticlePlant physiology2009
Rice virescent3 and stripe1 encoding the large and small subunits of ribonucleotide reductase are required for chloroplast biogenesis during early leaf development.
Article in Plant physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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89 citing papers in PubMed, 205 citations in OpenAlex.
- Mutation of OsKIF14.3, a Kinesin-14 Subfamily Protein, Altered Starch Metabolism and Caused Yellowish Leaf in Rice.International journal of molecular sciences · 2025Article
- Map-based cloning identifies a missense SNP in CsTRX z, encoding a z-type thioredoxin homolog, as the genetic determinant of Dominant Virescent Leaf in cucumber.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Chlorophyll deficient 5 encodes a DNA helicase and is essential for chloroplast development in rice.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Functional conservation and divergence of arabidopsis VENOSA4 and human SAMHD1 in DNA repair.Heliyon · 2025Article
- Fine mapping and expression characteristics analysis of male-sterile gene BrRNR1 in Chinese cabbage (Brassica rapa L. ssp. pekinensis).BMC plant biology · 2025Article
- Insight into the genetics of a novel white-striped leaf in rice.Frontiers in plant science · 2025Article
- A strategy for identification and characterization of genic mutations using a temperature-sensitive chlorotic soybean mutant as an example.Plant direct · 2024Article
- The RiceBiology · 2024Article
- Mapping and Candidate Gene Analysis of the Low-Temperature-Sensitive Albino GeneCurrent issues in molecular biology · 2024Article
- Albino lethal 13, a chloroplast-imported protein required for chloroplast development in rice.Plant direct · 2024Article
- Article
- Identification and characterization of a temperature sensitive chlorotic soybean mutant.bioRxiv : the preprint server for biology · 2024Article
- YGL3 Encoding an IPP and DMAPP Synthase Interacts with OsPIL11 to Regulate Chloroplast Development in Rice.Rice (New York, N.Y.) · 2024Article
- Physiological, Cytological, and Transcriptomic Analysis of Magnesium Protoporphyrin IX Methyltransferase Mutant Reveal Complex Genetic Regulatory Network Linking Chlorophyll Synthesis and Chloroplast Development in Rice.Plants (Basel, Switzerland) · 2023Article
- Maize LOST SUBSIDIARY CELL encoding a large subunit of ribonucleotide reductase is required for subsidiary cell development and plant growth.Journal of experimental botany · 2023Article
- Molecular and biochemical characterization of rice developed through conventional integration of nDart1-0 transposon gene.Scientific reports · 2023Article
- Narrow and Stripe Leaf 2 Regulates Leaf Width by Modulating Cell Cycle Progression in Rice.Rice (New York, N.Y.) · 2023Article
- RiceBiology · 2022Article
- OsWHY1 Interacts with OsTRX z and is Essential for Early Chloroplast Development in Rice.Rice (New York, N.Y.) · 2022Article
- Physiological analysis and transcriptome sequencing of a delayed-green leaf mutant 'Duojiao' of ornamental crabapple (Physiology and molecular biology of plants : an international journal of functional plant biology · 2022Article
29 more citing papers are in PubMed but not listed here.
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8 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The virescent3 (v3) and stripe1 (st1) mutants in rice (Oryza sativa) produce chlorotic leaves in a growth stage-dependent manner under field conditions. They are temperature-conditional mutants that produce bleached leaves at a constant 20 degrees C or 30 degrees C but almost green leaves under diurnal 30 degrees C/20 degrees C conditions. Here, we show V3 and St1, which encode the large and small subunits of ribonucleotide reductase (RNR), RNRL1, and RNRS1, respectively. RNR regulates the rate of deoxyribonucleotide production for DNA synthesis and repair. RNRL1 and RNRS1 are highly expressed in the shoot base and in young leaves, and the expression of the genes that function in plastid transcription/translation and in photosynthesis is altered in v3 and st1 mutants, indicating that a threshold activity of RNR is required for chloroplast biogenesis in developing leaves. There are additional RNR homologs in rice, RNRL2 and RNRS2, and eukaryotic RNRs comprise alpha(2)beta(2) heterodimers. In yeast, RNRL1 interacts with RNRS1 (RNRL1:RNRS1) and RNRL2:RNRS2, but no interaction occurs between other combinations of the large and small subunits. The interacting activities are RNRL1:RNRS1 > RNRL1:rnrs1(st1) > rnrl1(v3):RNRS1 > rnrl1(v3):rnrs1(st1), which correlate with the degree of chlorosis for each genotype. This suggests that missense mutations in rnrl1(v3) and rnrs1(st1) attenuate the first alphabeta dimerization. Moreover, wild-type plants exposed to a low concentration of an RNR inhibitor, hydroxyurea, produce chlorotic leaves without growth retardation, reminiscent of v3 and st1 mutants. We thus propose that upon insufficient activity of RNR, plastid DNA synthesis is preferentially arrested to allow nuclear genome replication in developing leaves, leading to continuous plant growth.
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