ArticleMolecular biology of the cell2009
Tetrahymena meiotic nuclear reorganization is induced by a checkpoint kinase-dependent response to DNA damage.
Article in Molecular biology of the cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Noncanonical usage of stop codons in ciliates expands proteins with structurally flexible Q-rich motifs.eLife · 2024Article
- Mismatch Repair Protein Msh2 Is Necessary for Macronuclear Stability and Micronuclear Division inInternational journal of molecular sciences · 2023Article
- A practical reference for studying meiosis in the model ciliateMarine life science & technology · 2022Review
- Review
- Arrested crossover precursor structures form stable homologous bonds in a Tetrahymena meiotic mutant.PloS one · 2022Article
- Tetrahymena meiosis: Simple yet ingenious.PLoS genetics · 2021Review
- Phospho-Regulation of Meiotic Prophase.Frontiers in cell and developmental biology · 2021Review
- Spatial constraints on chromosomes are instrumental to meiotic pairing.Journal of cell science · 2020Article
- An MCM family protein promotes interhomolog recombination by preventing precocious intersister repair of meiotic DSBs.PLoS genetics · 2019Article
- Noncanonical Contributions of MutLγ to VDE-Initiated Crossovers DuringG3 (Bethesda, Md.) · 2019Article
- A chromatin-associated protein required for inducing and limiting meiotic DNA double-strand break formation.Nucleic acids research · 2018Article
- Post-meiotic DNA double-strand breaks occur ineLife · 2017Article
- A Zip3-like protein plays a role in crossover formation in the SC-less meiosis of the protistMolecular biology of the cell · 2017Article
- E2fl1 is a meiosis-specific transcription factor in the protist Tetrahymena thermophila.Cell cycle (Georgetown, Tex.) · 2017Article
- Article
- The key role of CYC2 during meiosis in Tetrahymena thermophila.Protein & cell · 2016Article
- Checkpoint Activation of an Unconventional DNA Replication Program in Tetrahymena.PLoS genetics · 2015Article
- Developmental regulation of the Tetrahymena thermophila origin recognition complex.PLoS genetics · 2015Article
- Msh4 and Msh5 function in SC-independent chiasma formation during the streamlined meiosis of Tetrahymena.Genetics · 2014Article
- The meiotic checkpoint network: step-by-step through meiotic prophase.Cold Spring Harbor perspectives in biology · 2014Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
In the ciliate Tetrahymena, meiotic micronuclei (MICs) undergo extreme elongation, and meiotic pairing and recombination take place within these elongated nuclei (the "crescents"). We have previously shown that elongation does not occur in the absence of Spo11p-induced DNA double-strand breaks (DSBs). Here we show that elongation is restored in spo11Delta mutants by various DNA-damaging agents including ones that may not cause DSBs to a notable extent. MIC elongation following Spo11p-induced DSBs or artificially induced DNA lesions is probably a DNA-damage response mediated by a phosphokinase signal transduction pathway, since it is suppressed by the ATM/ATR kinase inhibitors caffeine and wortmannin and by knocking out Tetrahymena's ATR orthologue. MIC elongation occurs concomitantly with the movement of centromeres away from the telomeric pole of the MIC. This DNA damage-dependent reorganization of the MIC helps to arrange homologous chromosomes alongside each other but is not sufficient for exact pairing. Thus, Spo11p contributes to bivalent formation in two ways: by creating a favorable spatial disposition of homologues and by stabilizing pairing by crossovers. The polarized chromosome orientation inside the crescent resembles the conserved meiotic bouquet, and crescent and bouquet also share the putative function of aiding meiotic pairing. However, they are regulated differently because in Tetrahymena, DSBs are required for entering rather than exiting this stage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.