ArticleJournal of virology2009
Cell-to-cell spread of the RNA interference response suppresses Semliki Forest virus (SFV) infection of mosquito cell cultures and cannot be antagonized by SFV.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- RNA interference mediated mortality in Aedes albopictus: a challenging journey toward species-specific vector control.Parasites & vectors · 2025Article
- Gene silencing in the aedine cell lines C6/36 and U4.4 using long double-stranded RNA.Parasites & vectors · 2024Article
- Arboviruses and the Challenge to Establish Systemic and Persistent Infections in Competent Mosquito Vectors: The Interaction With the RNAi Mechanism.Frontiers in physiology · 2019Review
- How Do Virus-Mosquito Interactions Lead to Viral Emergence?Trends in parasitology · 2018Review
- Characterization of the Zika virus induced small RNA response in Aedes aegypti cells.PLoS neglected tropical diseases · 2017Article
- The Antiviral RNAi Response in Vector and Non-vector Cells against Orthobunyaviruses.PLoS neglected tropical diseases · 2017Article
- Microscopic Visualisation of Zoonotic Arbovirus Replication in Tick Cell and Organ Cultures Using Semliki Forest Virus Reporter Systems.Veterinary sciences · 2016Article
- Drosophila cells use nanotube-like structures to transfer dsRNA and RNAi machinery between cells.Scientific reports · 2016Article
- Helicases in Antiviral Immunity: Dual Properties as Sensors and Effectors.Trends in biochemical sciences · 2015Review
- RNA interference-mediated antiviral defense in insects.Current opinion in insect science · 2015Article
- Review
- Antiviral immunity of Anopheles gambiae is highly compartmentalized, with distinct roles for RNA interference and gut microbiota.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Mosquito immunity against arboviruses.Viruses · 2014Review
- Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replication.PLoS neglected tropical diseases · 2014Article
- Antiviral responses of arthropod vectors: an update on recent advances.Virusdisease · 2014Review
- The role of innate immunity in conditioning mosquito susceptibility to West Nile virus.Viruses · 2013Review
- Discovery of a unique novel clade of mosquito-associated bunyaviruses.Journal of virology · 2013Article
- Suppressors of RNAi from plant viruses are subject to episodic positive selection.Proceedings. Biological sciences · 2013Article
- Gene silencing in tick cell lines using small interfering or long double-stranded RNA.Experimental & applied acarology · 2013Article
- RNA interference targets arbovirus replication in Culicoides cells.Journal of virology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
In their vertebrate hosts, arboviruses such as Semliki Forest virus (SFV) (Togaviridae) generally counteract innate defenses and trigger cell death. In contrast, in mosquito cells, following an early phase of efficient virus production, a persistent infection with low levels of virus production is established. Whether arboviruses counteract RNA interference (RNAi), which provides an important antiviral defense system in mosquitoes, is an important question. Here we show that in Aedes albopictus-derived mosquito cells, SFV cannot prevent the establishment of an antiviral RNAi response or prevent the spread of protective antiviral double-stranded RNA/small interfering RNA (siRNA) from cell to cell, which can inhibit the replication of incoming virus. The expression of tombusvirus siRNA-binding protein p19 by SFV strongly enhanced virus spread between cultured cells rather than virus replication in initially infected cells. Our results indicate that the spread of the RNAi signal contributes to limiting virus dissemination.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.