ArticleCurrent opinion in chemical biology2009
Lessons from nature: unraveling biological CH bond activation.
Article in Current opinion in chemical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Unlocking Catalysis Using Oxidatively Induced Reductive Elimination.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Experimentally Assessing the Electronic Structure and Spin-State Energetics in MnFe Dimers Using 1s3p Resonant Inelastic X-ray Scattering.Inorganic chemistry · 2024Article
- IR spectroscopic characterization of [M,C,2H]Physical chemistry chemical physics : PCCP · 2024Article
- IR spectroscopic characterization of 3d transition metal carbene cations, FeCHPhysical chemistry chemical physics : PCCP · 2024Article
- The role of basicity in selective C-H bond activation by transition metal-oxidos.Dalton transactions (Cambridge, England : 2003) · 2023Review
- C-H Bond Cleavage by Bioinspired Nonheme Metal Complexes.Inorganic chemistry · 2021Review
- Influence of Thiolate versus Alkoxide Ligands on the Stability of Crystallographically Characterized Mn(III)-Alkylperoxo Complexes.Journal of the American Chemical Society · 2021Article
- Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases.Molecules (Basel, Switzerland) · 2020Review
- Direct Manipulation of Metal Imido Geometry: Key Principles to Enhance C-H Amination Efficacy.Journal of the American Chemical Society · 2019Article
- Regulating the Basicity of Metal-Oxido Complexes with a Single Hydrogen Bond and Its Effect on C-H Bond Cleavage.Journal of the American Chemical Society · 2019Article
- Equatorial Ligand Perturbations Influence the Reactivity of Manganese(IV)-Oxo Complexes.Angewandte Chemie (International ed. in English) · 2017Article
- The origin and evolution of ribonucleotide reduction.Life (Basel, Switzerland) · 2015Review
- Water-soluble Fe(II)-H2O complex with a weak O-H bond transfers a hydrogen atom via an observable monomeric Fe(III)-OH.Journal of the American Chemical Society · 2015Article
- Characterization of monomeric Mn(II/III/IV)-hydroxo complexes from X- and Q-band dual mode electron paramagnetic resonance (EPR) spectroscopy.Inorganic chemistry · 2013Article
- Reaction landscape of a pentadentate N5-ligated Mn(II) complex with O2˙- and H2O2 includes conversion of a peroxomanganese(III) adduct to a bis(μ-oxo)dimanganese(III,IV) species.Dalton transactions (Cambridge, England : 2003) · 2013Article
- Role of metal-oxo complexes in the cleavage of C-H bonds.Chemical Society reviews · 2011Article
- Role of the secondary coordination sphere in metal-mediated dioxygen activation.Inorganic chemistry · 2010Article
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2 authors.
Funding
Abstract
The cleavage of unactivated CH bonds is one of the most challenging reactions in chemical biology. Metalloenzymes have evolved that efficiently perform these transformations with exquisite control of selectivity; however, a proposed requirement is the generation of highly reactive intermediates that could be lethal. A thermodynamic argument involving the putative reactive species is outlined, whereby the interplay between two tunable parameters, redox potential and pK(a), may be the key to sustainable function. In addition, factors that control these parameters are also described, including hydrogen-bonding networks found within protein active sites. Synthetic examples are used to corroborate these ideas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.